TY - JOUR
T1 - Relationship between neural and hemodynamic signals during spontaneous activity studied with temporal kernel CCA
AU - Murayama, Yusuke
AU - Bießmann, Felix
AU - Meinecke, Frank C.
AU - Müller, Klaus Robert
AU - Augath, Mark
AU - Oeltermann, Axel
AU - Logothetis, Nikos K.
N1 - Funding Information:
We would like to thank M. Lindig and D. Ipek for technical support; S. Weber and K.H. Hofmann for their fine mechanics wizardry; J. Werner for computer assistance; and Dr. K. Whittingstall for discussions of an earlier manuscript. This work was supported by the Max Planck Society and has been supported as a Bernstein Cooperation (German Federal Ministry of Education and Science), Foerderkennzeichen 01 GQ 0711.
PY - 2010/10
Y1 - 2010/10
N2 - Functional magnetic resonance imaging (fMRI) based on the so-called blood oxygen level-dependent (BOLD) contrast is a powerful tool for studying brain function not only locally but also on the large scale. Most studies assume a simple relationship between neural and BOLD activity, in spite of the fact that it is important to elucidate how the "when" and "what" components of neural activity are correlated to the "where" of fMRI data. Here we conducted simultaneous recordings of neural and BOLD signal fluctuations in primary visual (V1) cortex of anesthetized monkeys. We explored the neurovascular relationship during periods of spontaneous activity by using temporal kernel canonical correlation analysis (tkCCA). tkCCA is a multivariate method that can take into account any features in the signals that univariate analysis cannot. The method detects filters in voxel space (for fMRI data) and in frequency-time space (for neural data) that maximize the neurovascular correlation without any assumption of a hemodynamic response function (HRF). Our results showed a positive neurovascular coupling with a lag of 4-5 s and a larger contribution from local field potentials (LFPs) in the γ range than from low-frequency LFPs or spiking activity. The method also detected a higher correlation around the recording site in the concurrent spatial map, even though the pattern covered most of the occipital part of V1. These results are consistent with those of previous studies and represent the first multivariate analysis of intracranial electrophysiology and high-resolution fMRI.
AB - Functional magnetic resonance imaging (fMRI) based on the so-called blood oxygen level-dependent (BOLD) contrast is a powerful tool for studying brain function not only locally but also on the large scale. Most studies assume a simple relationship between neural and BOLD activity, in spite of the fact that it is important to elucidate how the "when" and "what" components of neural activity are correlated to the "where" of fMRI data. Here we conducted simultaneous recordings of neural and BOLD signal fluctuations in primary visual (V1) cortex of anesthetized monkeys. We explored the neurovascular relationship during periods of spontaneous activity by using temporal kernel canonical correlation analysis (tkCCA). tkCCA is a multivariate method that can take into account any features in the signals that univariate analysis cannot. The method detects filters in voxel space (for fMRI data) and in frequency-time space (for neural data) that maximize the neurovascular correlation without any assumption of a hemodynamic response function (HRF). Our results showed a positive neurovascular coupling with a lag of 4-5 s and a larger contribution from local field potentials (LFPs) in the γ range than from low-frequency LFPs or spiking activity. The method also detected a higher correlation around the recording site in the concurrent spatial map, even though the pattern covered most of the occipital part of V1. These results are consistent with those of previous studies and represent the first multivariate analysis of intracranial electrophysiology and high-resolution fMRI.
KW - BOLD
KW - Canonical correlation
KW - Hemodynamic response function
KW - Local field potential
KW - Monkey
KW - Multi-unit activity
KW - Spontaneous activity
KW - Visual cortex
UR - http://www.scopus.com/inward/record.url?scp=77956881703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956881703&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2009.12.016
DO - 10.1016/j.mri.2009.12.016
M3 - Article
C2 - 20096530
AN - SCOPUS:77956881703
VL - 28
SP - 1095
EP - 1103
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 8
ER -