Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction

Seon Gyu Choi, Myung Ho Jeong, Youngkeun Ahn, Jeong Gwan Cho, Jung Chaee Kang, Shung Chull Chae, Seung Ho Hur, Taek Jong Hong, Young Jo Kim, In Whan Seong, Jei Keon Chae, Jay Young Rhew, In Ho Chae, Myeong Chan Cho, Jang Ho Bae, Seung-Woon Rha, Chong Jin Kim, Donghoon Choi, Yang Soo Jang, Junghan YoonWook Sung Chung, Ki Bae Seung, Seung Jung Park, Jong Hyun Kim, Dong Hoon Choi, Jae Young Rhew, Doo Il Kim, Jung Han Yoon, Bon Kwon Koo, Byung Ok Kim, Myoung Yong Lee, Kee Sik Kim, Jin Young Hwang, Seok Kyu Oh, Nae Hee Lee, Kyoung Tae Jeong, Seung Jea Tahk, Keum Soo Park, Kyoo Rok Han, Tae Hoon Ahn, Moo Hyun Kim, Ju Young Yang, Chong Yun Rhim, Hyeon Cheol Gwon, Seong Wook Park, Young Youp Koh, Seung Jae Joo, Soo Joong Kim, Dong Kyu Jin, Jin Man Cho, Sang Wook Kim, Jeong Kyung Kim, Tae Ik Kim, Deug Young Nah, Si Hoon Park, Sang Hyun Lee, Seung Uk Lee, Hang Jae Chung, Jang Hyun Cho, Seung Won Jin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalKorean Circulation Journal
Volume40
Issue number11
DOIs
Publication statusPublished - 2010 Nov 1

Fingerprint

Brain Natriuretic Peptide
Obesity
Myocardial Infarction
Body Mass Index
pro-brain natriuretic peptide (1-76)
Acute Coronary Syndrome
Korea
Registries
Heart Failure
Kidney

Keywords

  • Brain natriuretic peptide
  • Myocardial infarction
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction. / Choi, Seon Gyu; Jeong, Myung Ho; Ahn, Youngkeun; Cho, Jeong Gwan; Kang, Jung Chaee; Chae, Shung Chull; Hur, Seung Ho; Hong, Taek Jong; Kim, Young Jo; Seong, In Whan; Chae, Jei Keon; Rhew, Jay Young; Chae, In Ho; Cho, Myeong Chan; Bae, Jang Ho; Rha, Seung-Woon; Kim, Chong Jin; Choi, Donghoon; Jang, Yang Soo; Yoon, Junghan; Chung, Wook Sung; Seung, Ki Bae; Park, Seung Jung; Kim, Jong Hyun; Choi, Dong Hoon; Rhew, Jae Young; Kim, Doo Il; Yoon, Jung Han; Koo, Bon Kwon; Kim, Byung Ok; Lee, Myoung Yong; Kim, Kee Sik; Hwang, Jin Young; Oh, Seok Kyu; Lee, Nae Hee; Jeong, Kyoung Tae; Tahk, Seung Jea; Park, Keum Soo; Han, Kyoo Rok; Ahn, Tae Hoon; Kim, Moo Hyun; Yang, Ju Young; Rhim, Chong Yun; Gwon, Hyeon Cheol; Park, Seong Wook; Koh, Young Youp; Joo, Seung Jae; Kim, Soo Joong; Jin, Dong Kyu; Cho, Jin Man; Kim, Sang Wook; Kim, Jeong Kyung; Kim, Tae Ik; Nah, Deug Young; Park, Si Hoon; Lee, Sang Hyun; Lee, Seung Uk; Chung, Hang Jae; Cho, Jang Hyun; Jin, Seung Won.

In: Korean Circulation Journal, Vol. 40, No. 11, 01.11.2010, p. 558-564.

Research output: Contribution to journalArticle

Choi, SG, Jeong, MH, Ahn, Y, Cho, JG, Kang, JC, Chae, SC, Hur, SH, Hong, TJ, Kim, YJ, Seong, IW, Chae, JK, Rhew, JY, Chae, IH, Cho, MC, Bae, JH, Rha, S-W, Kim, CJ, Choi, D, Jang, YS, Yoon, J, Chung, WS, Seung, KB, Park, SJ, Kim, JH, Choi, DH, Rhew, JY, Kim, DI, Yoon, JH, Koo, BK, Kim, BO, Lee, MY, Kim, KS, Hwang, JY, Oh, SK, Lee, NH, Jeong, KT, Tahk, SJ, Park, KS, Han, KR, Ahn, TH, Kim, MH, Yang, JY, Rhim, CY, Gwon, HC, Park, SW, Koh, YY, Joo, SJ, Kim, SJ, Jin, DK, Cho, JM, Kim, SW, Kim, JK, Kim, TI, Nah, DY, Park, SH, Lee, SH, Lee, SU, Chung, HJ, Cho, JH & Jin, SW 2010, 'Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction', Korean Circulation Journal, vol. 40, no. 11, pp. 558-564. https://doi.org/10.4070/kcj.2010.40.11.558
Choi, Seon Gyu ; Jeong, Myung Ho ; Ahn, Youngkeun ; Cho, Jeong Gwan ; Kang, Jung Chaee ; Chae, Shung Chull ; Hur, Seung Ho ; Hong, Taek Jong ; Kim, Young Jo ; Seong, In Whan ; Chae, Jei Keon ; Rhew, Jay Young ; Chae, In Ho ; Cho, Myeong Chan ; Bae, Jang Ho ; Rha, Seung-Woon ; Kim, Chong Jin ; Choi, Donghoon ; Jang, Yang Soo ; Yoon, Junghan ; Chung, Wook Sung ; Seung, Ki Bae ; Park, Seung Jung ; Kim, Jong Hyun ; Choi, Dong Hoon ; Rhew, Jae Young ; Kim, Doo Il ; Yoon, Jung Han ; Koo, Bon Kwon ; Kim, Byung Ok ; Lee, Myoung Yong ; Kim, Kee Sik ; Hwang, Jin Young ; Oh, Seok Kyu ; Lee, Nae Hee ; Jeong, Kyoung Tae ; Tahk, Seung Jea ; Park, Keum Soo ; Han, Kyoo Rok ; Ahn, Tae Hoon ; Kim, Moo Hyun ; Yang, Ju Young ; Rhim, Chong Yun ; Gwon, Hyeon Cheol ; Park, Seong Wook ; Koh, Young Youp ; Joo, Seung Jae ; Kim, Soo Joong ; Jin, Dong Kyu ; Cho, Jin Man ; Kim, Sang Wook ; Kim, Jeong Kyung ; Kim, Tae Ik ; Nah, Deug Young ; Park, Si Hoon ; Lee, Sang Hyun ; Lee, Seung Uk ; Chung, Hang Jae ; Cho, Jang Hyun ; Jin, Seung Won. / Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction. In: Korean Circulation Journal. 2010 ; Vol. 40, No. 11. pp. 558-564.
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title = "Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction",
abstract = "Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70{\%}) and women (n=764, 30{\%}), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.",
keywords = "Brain natriuretic peptide, Myocardial infarction, Obesity",
author = "Choi, {Seon Gyu} and Jeong, {Myung Ho} and Youngkeun Ahn and Cho, {Jeong Gwan} and Kang, {Jung Chaee} and Chae, {Shung Chull} and Hur, {Seung Ho} and Hong, {Taek Jong} and Kim, {Young Jo} and Seong, {In Whan} and Chae, {Jei Keon} and Rhew, {Jay Young} and Chae, {In Ho} and Cho, {Myeong Chan} and Bae, {Jang Ho} and Seung-Woon Rha and Kim, {Chong Jin} and Donghoon Choi and Jang, {Yang Soo} and Junghan Yoon and Chung, {Wook Sung} and Seung, {Ki Bae} and Park, {Seung Jung} and Kim, {Jong Hyun} and Choi, {Dong Hoon} and Rhew, {Jae Young} and Kim, {Doo Il} and Yoon, {Jung Han} and Koo, {Bon Kwon} and Kim, {Byung Ok} and Lee, {Myoung Yong} and Kim, {Kee Sik} and Hwang, {Jin Young} and Oh, {Seok Kyu} and Lee, {Nae Hee} and Jeong, {Kyoung Tae} and Tahk, {Seung Jea} and Park, {Keum Soo} and Han, {Kyoo Rok} and Ahn, {Tae Hoon} and Kim, {Moo Hyun} and Yang, {Ju Young} and Rhim, {Chong Yun} and Gwon, {Hyeon Cheol} and Park, {Seong Wook} and Koh, {Young Youp} and Joo, {Seung Jae} and Kim, {Soo Joong} and Jin, {Dong Kyu} and Cho, {Jin Man} and Kim, {Sang Wook} and Kim, {Jeong Kyung} and Kim, {Tae Ik} and Nah, {Deug Young} and Park, {Si Hoon} and Lee, {Sang Hyun} and Lee, {Seung Uk} and Chung, {Hang Jae} and Cho, {Jang Hyun} and Jin, {Seung Won}",
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TY - JOUR

T1 - Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction

AU - Choi, Seon Gyu

AU - Jeong, Myung Ho

AU - Ahn, Youngkeun

AU - Cho, Jeong Gwan

AU - Kang, Jung Chaee

AU - Chae, Shung Chull

AU - Hur, Seung Ho

AU - Hong, Taek Jong

AU - Kim, Young Jo

AU - Seong, In Whan

AU - Chae, Jei Keon

AU - Rhew, Jay Young

AU - Chae, In Ho

AU - Cho, Myeong Chan

AU - Bae, Jang Ho

AU - Rha, Seung-Woon

AU - Kim, Chong Jin

AU - Choi, Donghoon

AU - Jang, Yang Soo

AU - Yoon, Junghan

AU - Chung, Wook Sung

AU - Seung, Ki Bae

AU - Park, Seung Jung

AU - Kim, Jong Hyun

AU - Choi, Dong Hoon

AU - Rhew, Jae Young

AU - Kim, Doo Il

AU - Yoon, Jung Han

AU - Koo, Bon Kwon

AU - Kim, Byung Ok

AU - Lee, Myoung Yong

AU - Kim, Kee Sik

AU - Hwang, Jin Young

AU - Oh, Seok Kyu

AU - Lee, Nae Hee

AU - Jeong, Kyoung Tae

AU - Tahk, Seung Jea

AU - Park, Keum Soo

AU - Han, Kyoo Rok

AU - Ahn, Tae Hoon

AU - Kim, Moo Hyun

AU - Yang, Ju Young

AU - Rhim, Chong Yun

AU - Gwon, Hyeon Cheol

AU - Park, Seong Wook

AU - Koh, Young Youp

AU - Joo, Seung Jae

AU - Kim, Soo Joong

AU - Jin, Dong Kyu

AU - Cho, Jin Man

AU - Kim, Sang Wook

AU - Kim, Jeong Kyung

AU - Kim, Tae Ik

AU - Nah, Deug Young

AU - Park, Si Hoon

AU - Lee, Sang Hyun

AU - Lee, Seung Uk

AU - Chung, Hang Jae

AU - Cho, Jang Hyun

AU - Jin, Seung Won

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

AB - Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

KW - Brain natriuretic peptide

KW - Myocardial infarction

KW - Obesity

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