Relationship between serum ferritin levels and dyslipidemia in Korean adolescents

Young Eun Kim, Do-Hoon Kim, Yong Kyun Roh, Sang Yhun Ju, Yeo Joon Yoon, Ga Eun Nam, Hyo Yun Nam, Jun Seok Choi, Jong Eun Lee, Jung Eun Sang, Kyungdo Han, Yong Gyu Park

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Abstract

Background Ferritin is associated with various cardiometabolic risk factors such as dyslipidemia, hypertension, obesity, and insulin resistance in adults. We aimed to study the association between serum ferritin levels and dyslipidemia in adolescents, because dyslipidemia is considered an important modifiable cardiovascular risk factor in the young. Methods We analyzed 1,879 subjects (1,026 boys and 853 girls) from the 2009-2010 Korean National Health and Nutrition Examination Survey IV. Subjects were categorized into quartiles according to their lipid parameters, which were classified according to age and gender. Those in the highest quartile groups for total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride concentrations were diagnosed as having dyslipidemia. Those in the lowest quartile for high-density lipoprotein cholesterol (HDL-C) values were diagnosed with abnormal levels. Results In boys, total cholesterol, LDL-C, and triglyceride concentrations were significantly correlated with serum ferritin levels. In both boys and girls, serum ferritin levels were negatively associated with HDL-C values, even after adjusting for all covariates. Furthermore, there was no significant correlation between serum ferritin levels and total cholesterol, LDL, and triglyceride concentrations in girls. Conclusion Serum ferritin levels were significantly associated with major dyslipidemia parameters, more prominently in boys than in girls, and this association represents a cardiometabolic risk factor.

Original languageEnglish
Article numbere0153167
JournalPLoS One
Volume11
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kim, Y. E., Kim, D-H., Roh, Y. K., Ju, S. Y., Yoon, Y. J., Nam, G. E., Nam, H. Y., Choi, J. S., Lee, J. E., Sang, J. E., Han, K., & Park, Y. G. (2016). Relationship between serum ferritin levels and dyslipidemia in Korean adolescents. PLoS One, 11(4), [e0153167]. https://doi.org/10.1371/journal.pone.0153167