Relationship between the expression of fibulin-3 and anterior vaginal wall prolapse

K. H. Ahn, Tak Kim, Jun Young Hur, S. H. Kim, K. W. Lee, Y. T. Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Anterior vaginal wall prolapse is the most common type of pelvic organ prolapse. Vaginal wall samples were obtained from women with (n =12) and without (n =12) anterior vaginal wall prolapse. No reports have been published on the content of fibulin-3 in the vaginal walls of patients with prolapse; thus, we compared the expression of fibulin-3 in the vaginal walls of women with and without anterior vaginal wall prolapse. RT-PCR was performed to measure mRNA expression and the expression of protein was assessed by immunohistochemistry. Statistical analysis was performed to determine differences between the two groups of women. Age, parity and menopausal status did not differ between women with and without prolapse. The expressions of fibulin-3 mRNA and protein were not different between the prolapse and no prolapse groups. It is unlikely that abnormal expression of fibulin-3 has a major role in the pathogenesis of anterior vaginal wall prolapse.

Original languageEnglish
Pages (from-to)362-366
Number of pages5
JournalJournal of Obstetrics and Gynaecology
Volume32
Issue number4
DOIs
Publication statusPublished - 2012 May 1

Keywords

  • Anterior vaginal wall prolapse
  • Fibulin-3
  • POP

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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