Relationship between tissue plasminogen activator, plasminogen activator inhibitor and CT image in chronic subdural hematoma.

D. J. Lim, Y. G. Chung, Y. K. Park, J. H. Song, H. K. Lee, K. C. Lee, J. W. Chu, Y. S. Yang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The present study was performed to investigate the relationship between the concentrations of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) and the CT images in 23 cases of chronic subdural hematomas (SDHs). The concentrations of t-PA and PAI-1 were quantified by enzyme-linked immunosorbent assay (ELISA). Chronic SDHs were divided into five groups according to their appearance on computed tomography: high-density (n = 4), isodensity (n = 8), low-density (n = 5), mixed-density (n = 3), layering (n = 3) types. The volume of hematoma was measured with an image analyzing software program. The concentrations of t-PA were higher in layering (41.2 +/- 0.3 ng/ml, mean +/- standard error of the mean) and high-density (40.0 +/- 1.1 ng/ml) types compared to those of low-density (23.3 +/- 4.1 ng/ml) and iso-density (25.1 +/- 3.7 ng/ml) types. The concentrations of PAI-1 were lower in layering (95.9 +/- 1.0 ng/ml) and high-density (103.4 +/- 34.5 ng/ml) types compared to that of low-density (192.5 +/- 2.6 ng/ml) type. So the ratio between t-PA and PAI-1 (t-PA/PAI) was greater in layering and high-density types. The volume of hematoma was larger in mixed-density and layering types but statistically insignificant. These results presumably suggest that the ratio between t-PA and PAI concentration may contribute to the pathogenesis of the chronic SDH.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalJournal of Korean medical science
Volume10
Issue number5
DOIs
Publication statusPublished - 1995 Oct

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Relationship between tissue plasminogen activator, plasminogen activator inhibitor and CT image in chronic subdural hematoma.'. Together they form a unique fingerprint.

  • Cite this