Relationship between uric acid and metabolic syndrome according to menopausal status

Hee Jung Lee, Hyun Tae Park, Geum Joon Cho, Kyung Wook Yi, Ki Hoon Ahn, Jung Ho Shin, Tak Kim, Young Tae Kim, Jun Young Hur, Sun Haeng Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective. Uric acid, the levels of which have been shown to increase after menopause, has been associated with metabolic syndrome. The prevalence of metabolic syndrome has also been determined to increase after menopause. Therefore, we surmised that menopausal status-specific analyses for the characterisation of the relationship between uric acid and the metabolic syndrome were warranted. Methods. We included 1644 patients: 1018 premenopausal women and 626 postmenopausal women, all of whom participated in annual health examinations at Anam Hospital in Seoul, Korea, from January 2008 through December 2008. Results. On the multivariate logistic regression analysis, uric acid was identified as an independent risk factor for metabolic syndrome in both premenopausal and postmenopausal women. Uric acid levels had different relationships with blood pressure based on menopausal status, however, no such relationships with fasting glucose or age were found. Conclusions. Increased uric acid levels were associated with increased risk for metabolic syndrome in both premenopausal and postmenopausal women. In studies regarding uric acid and metabolic syndrome in women, the effects of menopausal status should be considered.

Original languageEnglish
Pages (from-to)406-411
Number of pages6
JournalGynecological Endocrinology
Volume27
Issue number6
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • Uric acid
  • menopausal status
  • metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynaecology

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    Lee, H. J., Park, H. T., Cho, G. J., Yi, K. W., Ahn, K. H., Shin, J. H., Kim, T., Kim, Y. T., Hur, J. Y., & Kim, S. H. (2011). Relationship between uric acid and metabolic syndrome according to menopausal status. Gynecological Endocrinology, 27(6), 406-411. https://doi.org/10.3109/09513590.2010.493962