Relationship between urinary sodium-creatinine ratios and insulin resistance in Korean children and adolescents with obesity

So Yoon Han, Nan Hee Kim, Do-Hoon Kim, Kyungdo Han, Seon Mee Kim

Research output: Contribution to journalArticle

Abstract

The prevalence of childhood obesity has significantly increased in Korea. This study aimed to use data from the 2010 Korea National Health and Nutrition Examination Survey (KNHANES) to investigate the association between sodium (Na) intake and insulin resistance in children and adolescents with obesity. The study population consisted of 578 adolescents aged 12-18 years who were enrolled in the 2010 KNHANES. Subjects were classified into the following four groups based on their body mass index (BMI) and homeostatic model assessment-insulin resistance (HOMA-IR) values: normal BMI and HOMA-IR (Group 1), normal BMI and ≥75% HOMA-IR (Group 2), ≥85% BMI and normal HOMA-IR (Group 3) and ≥85% BMI and ≥75% HOMA-IR (Group 4). The groups were further divided into four quartiles (Q1-Q4) based on urinary sodium-creatinine ratios (UNa/Cr) to analyze the association between obesity and metabolic abnormality as a result of increased Na intake. There were significant differences among the four groups in terms of abdominal obesity (p<0.000), waist circumference (WC) (p<0.000) blood glucose levels (p<0.000), insulin levels (p<0.000) and UNa/Cr, with Groups 2, 3 and 4 having significantly higher UNa/Cr than Group 1 (p=0.002). In addition, there was a significant positive correlation between UNa/Cr and obesity (Q1=1 vs. Q4=3.23, p=0.019) and metabolic abnormality (Q1=1 vs. Q4=2.25, p=0.167). Increased Na intake showed a positive statistical correlation with insulin resistance and is associated with an increased risk of insulin resistance and other metabolic abnormalities in obese children and adolescents.

Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalJournal of Pediatric Endocrinology and Metabolism
Volume31
Issue number4
DOIs
Publication statusPublished - 2018 Mar 28

Fingerprint

Pediatric Obesity
Insulin Resistance
Creatinine
Sodium
Body Mass Index
Korea
Nutrition Surveys
Obesity
Abdominal Obesity
Waist Circumference
Blood Glucose
Reference Values
Insulin
Population

Keywords

  • adolescents
  • body mass index
  • insulin resistance
  • obesity
  • urine sodium-creatinine ratio

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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title = "Relationship between urinary sodium-creatinine ratios and insulin resistance in Korean children and adolescents with obesity",
abstract = "The prevalence of childhood obesity has significantly increased in Korea. This study aimed to use data from the 2010 Korea National Health and Nutrition Examination Survey (KNHANES) to investigate the association between sodium (Na) intake and insulin resistance in children and adolescents with obesity. The study population consisted of 578 adolescents aged 12-18 years who were enrolled in the 2010 KNHANES. Subjects were classified into the following four groups based on their body mass index (BMI) and homeostatic model assessment-insulin resistance (HOMA-IR) values: normal BMI and HOMA-IR (Group 1), normal BMI and ≥75{\%} HOMA-IR (Group 2), ≥85{\%} BMI and normal HOMA-IR (Group 3) and ≥85{\%} BMI and ≥75{\%} HOMA-IR (Group 4). The groups were further divided into four quartiles (Q1-Q4) based on urinary sodium-creatinine ratios (UNa/Cr) to analyze the association between obesity and metabolic abnormality as a result of increased Na intake. There were significant differences among the four groups in terms of abdominal obesity (p<0.000), waist circumference (WC) (p<0.000) blood glucose levels (p<0.000), insulin levels (p<0.000) and UNa/Cr, with Groups 2, 3 and 4 having significantly higher UNa/Cr than Group 1 (p=0.002). In addition, there was a significant positive correlation between UNa/Cr and obesity (Q1=1 vs. Q4=3.23, p=0.019) and metabolic abnormality (Q1=1 vs. Q4=2.25, p=0.167). Increased Na intake showed a positive statistical correlation with insulin resistance and is associated with an increased risk of insulin resistance and other metabolic abnormalities in obese children and adolescents.",
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T1 - Relationship between urinary sodium-creatinine ratios and insulin resistance in Korean children and adolescents with obesity

AU - Han, So Yoon

AU - Kim, Nan Hee

AU - Kim, Do-Hoon

AU - Han, Kyungdo

AU - Kim, Seon Mee

PY - 2018/3/28

Y1 - 2018/3/28

N2 - The prevalence of childhood obesity has significantly increased in Korea. This study aimed to use data from the 2010 Korea National Health and Nutrition Examination Survey (KNHANES) to investigate the association between sodium (Na) intake and insulin resistance in children and adolescents with obesity. The study population consisted of 578 adolescents aged 12-18 years who were enrolled in the 2010 KNHANES. Subjects were classified into the following four groups based on their body mass index (BMI) and homeostatic model assessment-insulin resistance (HOMA-IR) values: normal BMI and HOMA-IR (Group 1), normal BMI and ≥75% HOMA-IR (Group 2), ≥85% BMI and normal HOMA-IR (Group 3) and ≥85% BMI and ≥75% HOMA-IR (Group 4). The groups were further divided into four quartiles (Q1-Q4) based on urinary sodium-creatinine ratios (UNa/Cr) to analyze the association between obesity and metabolic abnormality as a result of increased Na intake. There were significant differences among the four groups in terms of abdominal obesity (p<0.000), waist circumference (WC) (p<0.000) blood glucose levels (p<0.000), insulin levels (p<0.000) and UNa/Cr, with Groups 2, 3 and 4 having significantly higher UNa/Cr than Group 1 (p=0.002). In addition, there was a significant positive correlation between UNa/Cr and obesity (Q1=1 vs. Q4=3.23, p=0.019) and metabolic abnormality (Q1=1 vs. Q4=2.25, p=0.167). Increased Na intake showed a positive statistical correlation with insulin resistance and is associated with an increased risk of insulin resistance and other metabolic abnormalities in obese children and adolescents.

AB - The prevalence of childhood obesity has significantly increased in Korea. This study aimed to use data from the 2010 Korea National Health and Nutrition Examination Survey (KNHANES) to investigate the association between sodium (Na) intake and insulin resistance in children and adolescents with obesity. The study population consisted of 578 adolescents aged 12-18 years who were enrolled in the 2010 KNHANES. Subjects were classified into the following four groups based on their body mass index (BMI) and homeostatic model assessment-insulin resistance (HOMA-IR) values: normal BMI and HOMA-IR (Group 1), normal BMI and ≥75% HOMA-IR (Group 2), ≥85% BMI and normal HOMA-IR (Group 3) and ≥85% BMI and ≥75% HOMA-IR (Group 4). The groups were further divided into four quartiles (Q1-Q4) based on urinary sodium-creatinine ratios (UNa/Cr) to analyze the association between obesity and metabolic abnormality as a result of increased Na intake. There were significant differences among the four groups in terms of abdominal obesity (p<0.000), waist circumference (WC) (p<0.000) blood glucose levels (p<0.000), insulin levels (p<0.000) and UNa/Cr, with Groups 2, 3 and 4 having significantly higher UNa/Cr than Group 1 (p=0.002). In addition, there was a significant positive correlation between UNa/Cr and obesity (Q1=1 vs. Q4=3.23, p=0.019) and metabolic abnormality (Q1=1 vs. Q4=2.25, p=0.167). Increased Na intake showed a positive statistical correlation with insulin resistance and is associated with an increased risk of insulin resistance and other metabolic abnormalities in obese children and adolescents.

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KW - body mass index

KW - insulin resistance

KW - obesity

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