Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer

Hyo Sung Jeon, Kyung Mee Kim, Sun Ha Park, Su Yeon Lee, Jin Eun Choi, Ga Young Lee, Sin Kam, Rang Woon Park, In-San Kim, Chang Ho Kim, Tae Hoon Jung, Jae Yong Park

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

DNA repair plays a critical role in protecting the genome from insults of cancer-causing agents, such as those found in tobacco smoke. Therefore, reduced DNA repair capacity can increase the susceptibility to smoking-related cancers. Recently, several polymorphisms have been identified in the xeroderma pigmentosum group G (XPG) gene, and it is possible that these polymorphisms may affect the DNA repair capacity, thereby modulating cancer susceptibility. We investigated the relationship between the His1104Asp polymorphism in the XPG gene and the risk of lung cancer. The study population consisted of 310 lung cancer patients and 311 healthy controls who were frequency (1:1) matched based on age and sex. The Asp/Asp genotype was more frequent in the controls (28.9%) than in the cases (18.7%) and associated with a significantly decreased risk of lung cancer [adjusted odds ratio (OR) = 0.54, 95% confidence interval (CI) = 0.37-0.80] when the combined His/His and His/Asp genotype was used as the reference. The protective effect of the Asp/Asp genotype against lung cancer was statistically significant in the older subjects (adjusted OR = 0.51, 95 % CI = 0.37-0.80), males (adjusted OR = 0.54, 95% CI = 0.35-0.83), and lighter smokers (adjusted OR = 0.48, 95% CI = 0.25-0.94) in a stratification analysis. When the lung cancers were analyzed by histologic type, the Asp/Asp genotype was associated with a significantly decreased risk of squamous cell carcinoma (adjusted OR = 0.55, 95% CI = 0.34-0.88) and small cell lung cancer (adjusted OR = 0.44, 95 % CI = 0.20-0.97), but non-significant decreased risk of adenocarcinoma (adjusted OR = 0.64, 95% CI = 0.36-1.12). These results suggest that the XPG codon 1104 polymorphism contributes to genetic susceptibility to lung cancer.

Original languageEnglish
Pages (from-to)1677-1681
Number of pages5
JournalCarcinogenesis
Volume24
Issue number10
DOIs
Publication statusPublished - 2003 Oct 1
Externally publishedYes

Fingerprint

Xeroderma Pigmentosum
Viperidae
Codon
Lung Neoplasms
Odds Ratio
Confidence Intervals
Genotype
DNA Repair
Neoplasms
Small Cell Lung Carcinoma
Genetic Predisposition to Disease
Smoke
Genes
Tobacco
Squamous Cell Carcinoma
Adenocarcinoma
Smoking
Genome
Population

ASJC Scopus subject areas

  • Cancer Research

Cite this

Jeon, H. S., Kim, K. M., Park, S. H., Lee, S. Y., Choi, J. E., Lee, G. Y., ... Park, J. Y. (2003). Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer. Carcinogenesis, 24(10), 1677-1681. https://doi.org/10.1093/carcin/bgg120

Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer. / Jeon, Hyo Sung; Kim, Kyung Mee; Park, Sun Ha; Lee, Su Yeon; Choi, Jin Eun; Lee, Ga Young; Kam, Sin; Park, Rang Woon; Kim, In-San; Kim, Chang Ho; Jung, Tae Hoon; Park, Jae Yong.

In: Carcinogenesis, Vol. 24, No. 10, 01.10.2003, p. 1677-1681.

Research output: Contribution to journalArticle

Jeon, HS, Kim, KM, Park, SH, Lee, SY, Choi, JE, Lee, GY, Kam, S, Park, RW, Kim, I-S, Kim, CH, Jung, TH & Park, JY 2003, 'Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer', Carcinogenesis, vol. 24, no. 10, pp. 1677-1681. https://doi.org/10.1093/carcin/bgg120
Jeon HS, Kim KM, Park SH, Lee SY, Choi JE, Lee GY et al. Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer. Carcinogenesis. 2003 Oct 1;24(10):1677-1681. https://doi.org/10.1093/carcin/bgg120
Jeon, Hyo Sung ; Kim, Kyung Mee ; Park, Sun Ha ; Lee, Su Yeon ; Choi, Jin Eun ; Lee, Ga Young ; Kam, Sin ; Park, Rang Woon ; Kim, In-San ; Kim, Chang Ho ; Jung, Tae Hoon ; Park, Jae Yong. / Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer. In: Carcinogenesis. 2003 ; Vol. 24, No. 10. pp. 1677-1681.
@article{caf022ad7b03445086900a7c467fd142,
title = "Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer",
abstract = "DNA repair plays a critical role in protecting the genome from insults of cancer-causing agents, such as those found in tobacco smoke. Therefore, reduced DNA repair capacity can increase the susceptibility to smoking-related cancers. Recently, several polymorphisms have been identified in the xeroderma pigmentosum group G (XPG) gene, and it is possible that these polymorphisms may affect the DNA repair capacity, thereby modulating cancer susceptibility. We investigated the relationship between the His1104Asp polymorphism in the XPG gene and the risk of lung cancer. The study population consisted of 310 lung cancer patients and 311 healthy controls who were frequency (1:1) matched based on age and sex. The Asp/Asp genotype was more frequent in the controls (28.9{\%}) than in the cases (18.7{\%}) and associated with a significantly decreased risk of lung cancer [adjusted odds ratio (OR) = 0.54, 95{\%} confidence interval (CI) = 0.37-0.80] when the combined His/His and His/Asp genotype was used as the reference. The protective effect of the Asp/Asp genotype against lung cancer was statistically significant in the older subjects (adjusted OR = 0.51, 95 {\%} CI = 0.37-0.80), males (adjusted OR = 0.54, 95{\%} CI = 0.35-0.83), and lighter smokers (adjusted OR = 0.48, 95{\%} CI = 0.25-0.94) in a stratification analysis. When the lung cancers were analyzed by histologic type, the Asp/Asp genotype was associated with a significantly decreased risk of squamous cell carcinoma (adjusted OR = 0.55, 95{\%} CI = 0.34-0.88) and small cell lung cancer (adjusted OR = 0.44, 95 {\%} CI = 0.20-0.97), but non-significant decreased risk of adenocarcinoma (adjusted OR = 0.64, 95{\%} CI = 0.36-1.12). These results suggest that the XPG codon 1104 polymorphism contributes to genetic susceptibility to lung cancer.",
author = "Jeon, {Hyo Sung} and Kim, {Kyung Mee} and Park, {Sun Ha} and Lee, {Su Yeon} and Choi, {Jin Eun} and Lee, {Ga Young} and Sin Kam and Park, {Rang Woon} and In-San Kim and Kim, {Chang Ho} and Jung, {Tae Hoon} and Park, {Jae Yong}",
year = "2003",
month = "10",
day = "1",
doi = "10.1093/carcin/bgg120",
language = "English",
volume = "24",
pages = "1677--1681",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer

AU - Jeon, Hyo Sung

AU - Kim, Kyung Mee

AU - Park, Sun Ha

AU - Lee, Su Yeon

AU - Choi, Jin Eun

AU - Lee, Ga Young

AU - Kam, Sin

AU - Park, Rang Woon

AU - Kim, In-San

AU - Kim, Chang Ho

AU - Jung, Tae Hoon

AU - Park, Jae Yong

PY - 2003/10/1

Y1 - 2003/10/1

N2 - DNA repair plays a critical role in protecting the genome from insults of cancer-causing agents, such as those found in tobacco smoke. Therefore, reduced DNA repair capacity can increase the susceptibility to smoking-related cancers. Recently, several polymorphisms have been identified in the xeroderma pigmentosum group G (XPG) gene, and it is possible that these polymorphisms may affect the DNA repair capacity, thereby modulating cancer susceptibility. We investigated the relationship between the His1104Asp polymorphism in the XPG gene and the risk of lung cancer. The study population consisted of 310 lung cancer patients and 311 healthy controls who were frequency (1:1) matched based on age and sex. The Asp/Asp genotype was more frequent in the controls (28.9%) than in the cases (18.7%) and associated with a significantly decreased risk of lung cancer [adjusted odds ratio (OR) = 0.54, 95% confidence interval (CI) = 0.37-0.80] when the combined His/His and His/Asp genotype was used as the reference. The protective effect of the Asp/Asp genotype against lung cancer was statistically significant in the older subjects (adjusted OR = 0.51, 95 % CI = 0.37-0.80), males (adjusted OR = 0.54, 95% CI = 0.35-0.83), and lighter smokers (adjusted OR = 0.48, 95% CI = 0.25-0.94) in a stratification analysis. When the lung cancers were analyzed by histologic type, the Asp/Asp genotype was associated with a significantly decreased risk of squamous cell carcinoma (adjusted OR = 0.55, 95% CI = 0.34-0.88) and small cell lung cancer (adjusted OR = 0.44, 95 % CI = 0.20-0.97), but non-significant decreased risk of adenocarcinoma (adjusted OR = 0.64, 95% CI = 0.36-1.12). These results suggest that the XPG codon 1104 polymorphism contributes to genetic susceptibility to lung cancer.

AB - DNA repair plays a critical role in protecting the genome from insults of cancer-causing agents, such as those found in tobacco smoke. Therefore, reduced DNA repair capacity can increase the susceptibility to smoking-related cancers. Recently, several polymorphisms have been identified in the xeroderma pigmentosum group G (XPG) gene, and it is possible that these polymorphisms may affect the DNA repair capacity, thereby modulating cancer susceptibility. We investigated the relationship between the His1104Asp polymorphism in the XPG gene and the risk of lung cancer. The study population consisted of 310 lung cancer patients and 311 healthy controls who were frequency (1:1) matched based on age and sex. The Asp/Asp genotype was more frequent in the controls (28.9%) than in the cases (18.7%) and associated with a significantly decreased risk of lung cancer [adjusted odds ratio (OR) = 0.54, 95% confidence interval (CI) = 0.37-0.80] when the combined His/His and His/Asp genotype was used as the reference. The protective effect of the Asp/Asp genotype against lung cancer was statistically significant in the older subjects (adjusted OR = 0.51, 95 % CI = 0.37-0.80), males (adjusted OR = 0.54, 95% CI = 0.35-0.83), and lighter smokers (adjusted OR = 0.48, 95% CI = 0.25-0.94) in a stratification analysis. When the lung cancers were analyzed by histologic type, the Asp/Asp genotype was associated with a significantly decreased risk of squamous cell carcinoma (adjusted OR = 0.55, 95% CI = 0.34-0.88) and small cell lung cancer (adjusted OR = 0.44, 95 % CI = 0.20-0.97), but non-significant decreased risk of adenocarcinoma (adjusted OR = 0.64, 95% CI = 0.36-1.12). These results suggest that the XPG codon 1104 polymorphism contributes to genetic susceptibility to lung cancer.

UR - http://www.scopus.com/inward/record.url?scp=0142216546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142216546&partnerID=8YFLogxK

U2 - 10.1093/carcin/bgg120

DO - 10.1093/carcin/bgg120

M3 - Article

C2 - 12869423

AN - SCOPUS:0142216546

VL - 24

SP - 1677

EP - 1681

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 10

ER -