Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6

Hye Soon Park, Jung Yul Park, Rina Yu

Research output: Contribution to journalArticle

443 Citations (Scopus)

Abstract

Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume69
Issue number1
DOIs
Publication statusPublished - 2005 Jul 1

Fingerprint

Abdominal Obesity
Adiposity
C-Reactive Protein
Interleukin-6
Tumor Necrosis Factor-alpha
Waist Circumference
Body Mass Index
Serum
Cytokines
Abdominal Fat
Preexisting Condition Coverage
Waist-Hip Ratio
Intra-Abdominal Fat
Hip
Cross-Sectional Studies
Fats
Tomography
Regression Analysis
Weights and Measures
Neoplasms

Keywords

  • CRP
  • IL-6
  • Obesity
  • TNF-α
  • Visceral adiposity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. / Park, Hye Soon; Park, Jung Yul; Yu, Rina.

In: Diabetes Research and Clinical Practice, Vol. 69, No. 1, 01.07.2005, p. 29-35.

Research output: Contribution to journalArticle

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N2 - Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.

AB - Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.

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