TY - JOUR
T1 - Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6
AU - Park, Hye Soon
AU - Park, Jung Yul
AU - Yu, Rina
N1 - Funding Information:
This study was supported by a Grant from the Asan Institute for Life Science 2002-106 and a SRC fund to IRC at the University of Ulsan from the KOSEF and the Korean Ministry Science and Technology.
PY - 2005/7
Y1 - 2005/7
N2 - Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.
AB - Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and obesity and visceral adiposity. Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-α and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan. Results: Overall, serum concentrations of CRP, TNF-α and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects. Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.
KW - CRP
KW - IL-6
KW - Obesity
KW - TNF-α
KW - Visceral adiposity
UR - http://www.scopus.com/inward/record.url?scp=20444480549&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2004.11.007
DO - 10.1016/j.diabres.2004.11.007
M3 - Article
C2 - 15955385
AN - SCOPUS:20444480549
SN - 0168-8227
VL - 69
SP - 29
EP - 35
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 1
ER -
