Relationships between exhaled nitric oxide and atopy profiles in children with asthma

Won Nyung Jang, In Su Park, Chang Hee Choi, Siegfried Bauer, Samuel Harmin, Sung Chul Seo, Ic Sun Choi, Ji-Tae Choung, Young Yoo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization in asthmatic children. Methods: A total of 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examined sensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. The children were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and poly-sensitized). Results: The geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb [10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlated with serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees. Conclusions: FeNO levels vary according to the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlated with serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest risk of airway inflammation.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalAllergy, Asthma and Immunology Research
Volume5
Issue number3
DOIs
Publication statusPublished - 2013 May 1

Fingerprint

Nitric Oxide
Asthma
Eosinophil Cationic Protein
Immunoglobulin E
Serum
Eosinophilia
Dander
Pyroglyphidae
Cockroaches
Methacholine Chloride
Spirometry
Pollen
Skin Tests
Eosinophils
Fungi
Inflammation
Skin

Keywords

  • Asthma
  • Atopy
  • Child
  • Fractional exhaled nitric oxide
  • Mono-sensitization
  • Poly-sensitization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Relationships between exhaled nitric oxide and atopy profiles in children with asthma. / Jang, Won Nyung; Park, In Su; Choi, Chang Hee; Bauer, Siegfried; Harmin, Samuel; Seo, Sung Chul; Choi, Ic Sun; Choung, Ji-Tae; Yoo, Young.

In: Allergy, Asthma and Immunology Research, Vol. 5, No. 3, 01.05.2013, p. 155-161.

Research output: Contribution to journalArticle

Jang, Won Nyung ; Park, In Su ; Choi, Chang Hee ; Bauer, Siegfried ; Harmin, Samuel ; Seo, Sung Chul ; Choi, Ic Sun ; Choung, Ji-Tae ; Yoo, Young. / Relationships between exhaled nitric oxide and atopy profiles in children with asthma. In: Allergy, Asthma and Immunology Research. 2013 ; Vol. 5, No. 3. pp. 155-161.
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AU - Jang, Won Nyung

AU - Park, In Su

AU - Choi, Chang Hee

AU - Bauer, Siegfried

AU - Harmin, Samuel

AU - Seo, Sung Chul

AU - Choi, Ic Sun

AU - Choung, Ji-Tae

AU - Yoo, Young

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N2 - Purpose: We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization in asthmatic children. Methods: A total of 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examined sensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. The children were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and poly-sensitized). Results: The geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb [10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlated with serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees. Conclusions: FeNO levels vary according to the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlated with serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest risk of airway inflammation.

AB - Purpose: We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization in asthmatic children. Methods: A total of 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examined sensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. The children were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and poly-sensitized). Results: The geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb [10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlated with serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees. Conclusions: FeNO levels vary according to the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlated with serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest risk of airway inflammation.

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KW - Atopy

KW - Child

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KW - Mono-sensitization

KW - Poly-sensitization

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