Relationships between exhaled nitric oxide and atopy profiles in children with asthma

Won Nyung Jang, In Su Park, Chang Hee Choi, Siegfried Bauer, Samuel Harmin, Sung Chul Seo, Ic Sun Choi, Ji Tae Choung, Young Yoo

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Purpose: We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization in asthmatic children. Methods: A total of 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examined sensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. The children were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and poly-sensitized). Results: The geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb [10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlated with serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees. Conclusions: FeNO levels vary according to the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlated with serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest risk of airway inflammation.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalAllergy, Asthma and Immunology Research
Issue number3
Publication statusPublished - 2013 May
Externally publishedYes


  • Asthma
  • Atopy
  • Child
  • Fractional exhaled nitric oxide
  • Mono-sensitization
  • Poly-sensitization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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