Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: The Korean Sarcopenic Obesity Study

Tae Nyun Kim, Man Sik Park, Kang Il Lim, Hae Yoon Choi, Sae Jeong Yang, Hye-Jin Yoo, Hyun Joo Kang, Wook Song, Hyuk Choi, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

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Abstract

Objective: It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity (SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25[OH]D) levels on SO in Korean adults. Study subject/measurements This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index (SMI) of 1 SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area (VFA) ≥100 cm2. We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA. Results: The prevalence of SO was 17.8% in men and 24.9% in women. In women, the SO group had higher HOMA-IR and hsCRP levels compared with the non-SO group. In men, the 25[OH]D levels were significantly lower in the SO group than the non-SO group. Both hsCRP and HOMA-IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[OH]D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA-IR and 25[OH]D levels were independently associated with SO in men, while HOMA-IR and hsCRP were significant factors predicting SO in women. Conclusion Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population.

Original languageEnglish
Pages (from-to)525-532
Number of pages8
JournalClinical Endocrinology
Volume78
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

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Vitamin D
Insulin Resistance
Obesity
Inflammation
Sarcopenia
Homeostasis
C-Reactive Protein
Intra-Abdominal Fat
Skeletal Muscle
Vitamin D Deficiency
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status : The Korean Sarcopenic Obesity Study. / Kim, Tae Nyun; Park, Man Sik; Lim, Kang Il; Choi, Hae Yoon; Yang, Sae Jeong; Yoo, Hye-Jin; Kang, Hyun Joo; Song, Wook; Choi, Hyuk; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.

In: Clinical Endocrinology, Vol. 78, No. 4, 01.04.2013, p. 525-532.

Research output: Contribution to journalArticle

Kim, Tae Nyun ; Park, Man Sik ; Lim, Kang Il ; Choi, Hae Yoon ; Yang, Sae Jeong ; Yoo, Hye-Jin ; Kang, Hyun Joo ; Song, Wook ; Choi, Hyuk ; Baik, Sei-Hyun ; Choi, Dong Seop ; Choi, Kyung Mook. / Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status : The Korean Sarcopenic Obesity Study. In: Clinical Endocrinology. 2013 ; Vol. 78, No. 4. pp. 525-532.
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abstract = "Objective: It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity (SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25[OH]D) levels on SO in Korean adults. Study subject/measurements This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index (SMI) of 1 SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area (VFA) ≥100 cm2. We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA. Results: The prevalence of SO was 17.8{\%} in men and 24.9{\%} in women. In women, the SO group had higher HOMA-IR and hsCRP levels compared with the non-SO group. In men, the 25[OH]D levels were significantly lower in the SO group than the non-SO group. Both hsCRP and HOMA-IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[OH]D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA-IR and 25[OH]D levels were independently associated with SO in men, while HOMA-IR and hsCRP were significant factors predicting SO in women. Conclusion Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population.",
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T1 - Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status

T2 - The Korean Sarcopenic Obesity Study

AU - Kim, Tae Nyun

AU - Park, Man Sik

AU - Lim, Kang Il

AU - Choi, Hae Yoon

AU - Yang, Sae Jeong

AU - Yoo, Hye-Jin

AU - Kang, Hyun Joo

AU - Song, Wook

AU - Choi, Hyuk

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Objective: It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity (SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25[OH]D) levels on SO in Korean adults. Study subject/measurements This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index (SMI) of 1 SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area (VFA) ≥100 cm2. We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA. Results: The prevalence of SO was 17.8% in men and 24.9% in women. In women, the SO group had higher HOMA-IR and hsCRP levels compared with the non-SO group. In men, the 25[OH]D levels were significantly lower in the SO group than the non-SO group. Both hsCRP and HOMA-IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[OH]D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA-IR and 25[OH]D levels were independently associated with SO in men, while HOMA-IR and hsCRP were significant factors predicting SO in women. Conclusion Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population.

AB - Objective: It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity (SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25[OH]D) levels on SO in Korean adults. Study subject/measurements This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index (SMI) of 1 SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area (VFA) ≥100 cm2. We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA. Results: The prevalence of SO was 17.8% in men and 24.9% in women. In women, the SO group had higher HOMA-IR and hsCRP levels compared with the non-SO group. In men, the 25[OH]D levels were significantly lower in the SO group than the non-SO group. Both hsCRP and HOMA-IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[OH]D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA-IR and 25[OH]D levels were independently associated with SO in men, while HOMA-IR and hsCRP were significant factors predicting SO in women. Conclusion Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population.

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