Release behavior of olmesartan medoxomil from solid dispersion prepared by PVP addition

Seung Chang Oh, Cheon Jung Lee, Hyun Gu Lee, Jin Young Park, Hyun Ki Jeong, Young Lae Kim, Dong-Kwon Lim, Dongwon Lee, Gilson Khang

Research output: Contribution to journalArticle

Abstract

Olmesartan affiliated to biopharmaceutics classification system class 2 is a poorly water soluble drug. For this reason, olmesartan showed a low bioavailability and a lot of difficulties in the process of designing the pharmaceutical formulation. We prepared the solid dispersions of olmesartan. We confirmed the dissolution rate of drug which was prepared by manufacturing. The pharmaceutical formulation of solid dispersions was designed by using PVP as water soluble polymer. We analyzed morphological feature of solid dispersion by employing a scanning electron microscope. Then, the crystalline property of solid dispersion was confirmed through X-ray diffraction and differential scanning calorimeter. Also, the chemical change of solid dispersion was confirmed by the Fourier transform infrared spectroscopy. In vitro dissolution test was used to analyze the dissolution rate of solid dispersion. The prepared solid dissolution olmesartan confirmed the dissolution rate in the pH 1.2. It was compared with olmetec and improved dissolution rate through solid dispersion.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalPolymer (Korea)
Volume39
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

Keywords

  • Olmesartan
  • PVP K30
  • Rotary evaporation
  • Solid dispersion
  • Spray-dry

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

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  • Cite this

    Oh, S. C., Lee, C. J., Lee, H. G., Park, J. Y., Jeong, H. K., Kim, Y. L., Lim, D-K., Lee, D., & Khang, G. (2015). Release behavior of olmesartan medoxomil from solid dispersion prepared by PVP addition. Polymer (Korea), 39(1), 33-39. https://doi.org/10.7317/pk.2015.39.1.33