Release of all-trans retinoic acid (RA) from RA-loaded poly (ester amine) based on polyethylenimine and polycaprolactone for intracellular delivery

Ding Ding Guo; Rohidas Arote; Hu Lin Jiang; Mi Kyong Yoo; Hyun Seuk Moon; Ng Su Cho

doi:10.4028/0-87849-436-7.429

Release of all-trans retinoic acid (RA) from RA-loaded poly (ester amine) based on polyethylenimine and polycaprolactone for intracellular delivery

Ding Ding Guo, Rohidas Arote, Hu Lin Jiang, Mi Kyong Yoo, Hyun Seuk Moon, Ng Su Cho

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

The objective of this study is to develop a new type of cationic nanoparticles for the intracellular drug delivery to breast cancer. Poly(ester amine) (PEA) based on polyethylenimine and polycaprolactone was synthesized to make cationic PEA nanoparticles for all-trans retinoic acid (RA). In the ¹H-NMR study, the proton signals of RA appeared in the spectrum of RA-loaded PEA nanoparticles in CDCL₃, whereas they disappeared in D₂O, suggesting that hydrophobic inner-core with hydrophilic outer-shell formed in water. RA release was faster at lower drug content and RA was released over a period of 20 days. RA-loaded PEA nanoparticles showed enhanced cytotoxicity compared with RA itself, whereas nanoparticles of PEA themselves did not show it. These results indicated that the cationic PEA provided an efficient intracellular delivery of RA.

Original language	English
Pages (from-to)	429-432
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.429
Publication status	Published - 2007

Keywords

All-trans retinoic acid
Intracellular delivery
Nanoparticle
Polycaprolactone
Polyethylenimine

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4028/0-87849-436-7.429

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title = "Release of all-trans retinoic acid (RA) from RA-loaded poly (ester amine) based on polyethylenimine and polycaprolactone for intracellular delivery",

abstract = "The objective of this study is to develop a new type of cationic nanoparticles for the intracellular drug delivery to breast cancer. Poly(ester amine) (PEA) based on polyethylenimine and polycaprolactone was synthesized to make cationic PEA nanoparticles for all-trans retinoic acid (RA). In the 1H-NMR study, the proton signals of RA appeared in the spectrum of RA-loaded PEA nanoparticles in CDCL3, whereas they disappeared in D2O, suggesting that hydrophobic inner-core with hydrophilic outer-shell formed in water. RA release was faster at lower drug content and RA was released over a period of 20 days. RA-loaded PEA nanoparticles showed enhanced cytotoxicity compared with RA itself, whereas nanoparticles of PEA themselves did not show it. These results indicated that the cationic PEA provided an efficient intracellular delivery of RA.",

keywords = "All-trans retinoic acid, Intracellular delivery, Nanoparticle, Polycaprolactone, Polyethylenimine",

author = "Guo, {Ding Ding} and Rohidas Arote and Jiang, {Hu Lin} and Yoo, {Mi Kyong} and Moon, {Hyun Seuk} and Cho, {Ng Su}",

year = "2007",

doi = "10.4028/0-87849-436-7.429",

language = "English",

volume = "342-343",

pages = "429--432",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications",

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TY - JOUR

T1 - Release of all-trans retinoic acid (RA) from RA-loaded poly (ester amine) based on polyethylenimine and polycaprolactone for intracellular delivery

AU - Guo, Ding Ding

AU - Arote, Rohidas

AU - Jiang, Hu Lin

AU - Yoo, Mi Kyong

AU - Moon, Hyun Seuk

AU - Cho, Ng Su

PY - 2007

Y1 - 2007

N2 - The objective of this study is to develop a new type of cationic nanoparticles for the intracellular drug delivery to breast cancer. Poly(ester amine) (PEA) based on polyethylenimine and polycaprolactone was synthesized to make cationic PEA nanoparticles for all-trans retinoic acid (RA). In the 1H-NMR study, the proton signals of RA appeared in the spectrum of RA-loaded PEA nanoparticles in CDCL3, whereas they disappeared in D2O, suggesting that hydrophobic inner-core with hydrophilic outer-shell formed in water. RA release was faster at lower drug content and RA was released over a period of 20 days. RA-loaded PEA nanoparticles showed enhanced cytotoxicity compared with RA itself, whereas nanoparticles of PEA themselves did not show it. These results indicated that the cationic PEA provided an efficient intracellular delivery of RA.

AB - The objective of this study is to develop a new type of cationic nanoparticles for the intracellular drug delivery to breast cancer. Poly(ester amine) (PEA) based on polyethylenimine and polycaprolactone was synthesized to make cationic PEA nanoparticles for all-trans retinoic acid (RA). In the 1H-NMR study, the proton signals of RA appeared in the spectrum of RA-loaded PEA nanoparticles in CDCL3, whereas they disappeared in D2O, suggesting that hydrophobic inner-core with hydrophilic outer-shell formed in water. RA release was faster at lower drug content and RA was released over a period of 20 days. RA-loaded PEA nanoparticles showed enhanced cytotoxicity compared with RA itself, whereas nanoparticles of PEA themselves did not show it. These results indicated that the cationic PEA provided an efficient intracellular delivery of RA.

KW - All-trans retinoic acid

KW - Intracellular delivery

KW - Nanoparticle

KW - Polycaprolactone

KW - Polyethylenimine

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DO - 10.4028/0-87849-436-7.429

M3 - Article

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VL - 342-343

SP - 429

EP - 432

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -

Release of all-trans retinoic acid (RA) from RA-loaded poly (ester amine) based on polyethylenimine and polycaprolactone for intracellular delivery

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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