Abstract
The objective of this study is to develop a new type of cationic nanoparticles for the intracellular drug delivery to breast cancer. Poly(ester amine) (PEA) based on polyethylenimine and polycaprolactone was synthesized to make cationic PEA nanoparticles for all-trans retinoic acid (RA). In the 1H-NMR study, the proton signals of RA appeared in the spectrum of RA-loaded PEA nanoparticles in CDCL3, whereas they disappeared in D2O, suggesting that hydrophobic inner-core with hydrophilic outer-shell formed in water. RA release was faster at lower drug content and RA was released over a period of 20 days. RA-loaded PEA nanoparticles showed enhanced cytotoxicity compared with RA itself, whereas nanoparticles of PEA themselves did not show it. These results indicated that the cationic PEA provided an efficient intracellular delivery of RA.
| Original language | English |
|---|---|
| Pages (from-to) | 429-432 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 342-343 |
| Publication status | Published - 2007 Apr 16 |
| Externally published | Yes |
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Keywords
- All-trans retinoic acid
- Intracellular delivery
- Nanoparticle
- Polycaprolactone
- Polyethylenimine
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Ceramics and Composites
Cite this
Release of all-trans retinoic acid (RA) from RA-loaded poly (ester amine) based on polyethylenimine and polycaprolactone for intracellular delivery. / Guo, DingDing; Arote, Rohidas; Jiang, Hu L.; Yoo, Mi Kyong; Moon, Hyun-Seuk; Cho, Ng S.
In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 429-432.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Release of all-trans retinoic acid (RA) from RA-loaded poly (ester amine) based on polyethylenimine and polycaprolactone for intracellular delivery
AU - Guo, DingDing
AU - Arote, Rohidas
AU - Jiang, Hu L.
AU - Yoo, Mi Kyong
AU - Moon, Hyun-Seuk
AU - Cho, Ng S.
PY - 2007/4/16
Y1 - 2007/4/16
N2 - The objective of this study is to develop a new type of cationic nanoparticles for the intracellular drug delivery to breast cancer. Poly(ester amine) (PEA) based on polyethylenimine and polycaprolactone was synthesized to make cationic PEA nanoparticles for all-trans retinoic acid (RA). In the 1H-NMR study, the proton signals of RA appeared in the spectrum of RA-loaded PEA nanoparticles in CDCL3, whereas they disappeared in D2O, suggesting that hydrophobic inner-core with hydrophilic outer-shell formed in water. RA release was faster at lower drug content and RA was released over a period of 20 days. RA-loaded PEA nanoparticles showed enhanced cytotoxicity compared with RA itself, whereas nanoparticles of PEA themselves did not show it. These results indicated that the cationic PEA provided an efficient intracellular delivery of RA.
AB - The objective of this study is to develop a new type of cationic nanoparticles for the intracellular drug delivery to breast cancer. Poly(ester amine) (PEA) based on polyethylenimine and polycaprolactone was synthesized to make cationic PEA nanoparticles for all-trans retinoic acid (RA). In the 1H-NMR study, the proton signals of RA appeared in the spectrum of RA-loaded PEA nanoparticles in CDCL3, whereas they disappeared in D2O, suggesting that hydrophobic inner-core with hydrophilic outer-shell formed in water. RA release was faster at lower drug content and RA was released over a period of 20 days. RA-loaded PEA nanoparticles showed enhanced cytotoxicity compared with RA itself, whereas nanoparticles of PEA themselves did not show it. These results indicated that the cationic PEA provided an efficient intracellular delivery of RA.
KW - All-trans retinoic acid
KW - Intracellular delivery
KW - Nanoparticle
KW - Polycaprolactone
KW - Polyethylenimine
UR - http://www.scopus.com/inward/record.url?scp=34147105072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147105072&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:34147105072
VL - 342-343
SP - 429
EP - 432
JO - Key Engineering Materials
JF - Key Engineering Materials
SN - 1013-9826
ER -