Abstract
We prepared temperature-sensitive liposomes (TS-liposomes) modified with a thermosensitive polymer, such as poly(N-isopropylacrylamide) (PNIPAAm), to increase the degree of drug release from liposomes at the hyperthermic temperature. A PNIPAAm hydrogel containing TS-liposomes was also prepared to obtain a hydrogel complex at body temperature. In addition, a depot system for local drug delivery using the polymer hydrogel was developed to enhance therapeutic efficacy and prevent severe side effects in the whole body. The PNIPAAm-modified TS-liposome was fixed into the PNIPAAm hydrogel having a high temperature-sensitivity. The release behavior of calcein, a model drug, from TS-liposomes in the PNIPAAm hydrogel was then initiated by external hyperthermia; the results indicated that sustained release as a function of temperature and time was caused by the thermosensitivity of the liposome surface and diffusion of the drug into the PNIPAAm hydrogel. Our results indicated that TS-liposomes in a PNIPAAm hydrogel represented a plausible system for local drug delivery.
Original language | English |
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Pages (from-to) | 54-61 |
Number of pages | 8 |
Journal | Macromolecular Research |
Volume | 13 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2005 Feb |
Externally published | Yes |
Keywords
- Calcein
- Depot system
- Hydrogel
- Liposome
- Poly(N-isopropylacrylamide)
ASJC Scopus subject areas
- Chemical Engineering(all)
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry