Abstract
We prepared temperature-sensitive liposomes (TS-liposomes) modified with a thermosensitive polymer, such as poly(N-isopropylacrylamide) (PNIPAAm), to increase the degree of drug release from liposomes at the hyperthermic temperature. A PNIPAAm hydrogel containing TS-liposomes was also prepared to obtain a hydrogel complex at body temperature. In addition, a depot system for local drug delivery using the polymer hydrogel was developed to enhance therapeutic efficacy and prevent severe side effects in the whole body. The PNIPAAm-modified TS-liposome was fixed into the PNIPAAm hydrogel having a high temperature-sensitivity. The release behavior of calcein, a model drug, from TS-liposomes in the PNIPAAm hydrogel was then initiated by external hyperthermia; the results indicated that sustained release as a function of temperature and time was caused by the thermosensitivity of the liposome surface and diffusion of the drug into the PNIPAAm hydrogel. Our results indicated that TS-liposomes in a PNIPAAm hydrogel represented a plausible system for local drug delivery.
| Original language | English |
|---|---|
| Pages (from-to) | 54-61 |
| Number of pages | 8 |
| Journal | Macromolecular Research |
| Volume | 13 |
| Issue number | 1 |
| Publication status | Published - 2005 Feb 1 |
| Externally published | Yes |
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Keywords
- Calcein
- Depot system
- Hydrogel
- Liposome
- Poly(N-isopropylacrylamide)
ASJC Scopus subject areas
- Polymers and Plastics
- Materials Chemistry
Cite this
Release of calcein from temperature-sensitive liposomes in a poly(N-isopropylacrylamide) hydrogel. / Hee, Dong Han; Kim, Tae Woo; Byung, Cheol Shin; Ho, Suk Choi.
In: Macromolecular Research, Vol. 13, No. 1, 01.02.2005, p. 54-61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Release of calcein from temperature-sensitive liposomes in a poly(N-isopropylacrylamide) hydrogel
AU - Hee, Dong Han
AU - Kim, Tae Woo
AU - Byung, Cheol Shin
AU - Ho, Suk Choi
PY - 2005/2/1
Y1 - 2005/2/1
N2 - We prepared temperature-sensitive liposomes (TS-liposomes) modified with a thermosensitive polymer, such as poly(N-isopropylacrylamide) (PNIPAAm), to increase the degree of drug release from liposomes at the hyperthermic temperature. A PNIPAAm hydrogel containing TS-liposomes was also prepared to obtain a hydrogel complex at body temperature. In addition, a depot system for local drug delivery using the polymer hydrogel was developed to enhance therapeutic efficacy and prevent severe side effects in the whole body. The PNIPAAm-modified TS-liposome was fixed into the PNIPAAm hydrogel having a high temperature-sensitivity. The release behavior of calcein, a model drug, from TS-liposomes in the PNIPAAm hydrogel was then initiated by external hyperthermia; the results indicated that sustained release as a function of temperature and time was caused by the thermosensitivity of the liposome surface and diffusion of the drug into the PNIPAAm hydrogel. Our results indicated that TS-liposomes in a PNIPAAm hydrogel represented a plausible system for local drug delivery.
AB - We prepared temperature-sensitive liposomes (TS-liposomes) modified with a thermosensitive polymer, such as poly(N-isopropylacrylamide) (PNIPAAm), to increase the degree of drug release from liposomes at the hyperthermic temperature. A PNIPAAm hydrogel containing TS-liposomes was also prepared to obtain a hydrogel complex at body temperature. In addition, a depot system for local drug delivery using the polymer hydrogel was developed to enhance therapeutic efficacy and prevent severe side effects in the whole body. The PNIPAAm-modified TS-liposome was fixed into the PNIPAAm hydrogel having a high temperature-sensitivity. The release behavior of calcein, a model drug, from TS-liposomes in the PNIPAAm hydrogel was then initiated by external hyperthermia; the results indicated that sustained release as a function of temperature and time was caused by the thermosensitivity of the liposome surface and diffusion of the drug into the PNIPAAm hydrogel. Our results indicated that TS-liposomes in a PNIPAAm hydrogel represented a plausible system for local drug delivery.
KW - Calcein
KW - Depot system
KW - Hydrogel
KW - Liposome
KW - Poly(N-isopropylacrylamide)
UR - http://www.scopus.com/inward/record.url?scp=14844293118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14844293118&partnerID=8YFLogxK
M3 - Article
VL - 13
SP - 54
EP - 61
JO - Macromolecular Research
JF - Macromolecular Research
SN - 1598-5032
IS - 1
ER -