Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells

Heemin Kang, Hee Joon Jung, Dexter Siu Hong Wong, Sung Kyu Kim, Sien Lin, Kai Fung Chan, Li Zhang, Gang Li, Vinayak P. Dravid, Liming Bian

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Remote, noninvasive, and reversible control over the nanoscale presentation of bioactive ligands, such as Arg-Gly-Asp (RGD) peptide, is highly desirable for temporally regulating cellular functions in vivo. Herein, we present a novel strategy for physically uncaging RGD using a magnetic field that allows safe and deep tissue penetration. We developed a heterodimeric nanoswitch consisting of a magnetic nanocage (MNC) coupled to an underlying RGD-coated gold nanoparticle (AuNP) via a long flexible linker. Magnetically controlled movement of MNC relative to AuNP allowed reversible uncaging and caging of RGD that modulate physical accessibility of RGD for integrin binding, thereby regulating stem cell adhesion, both in vitro and in vivo. Reversible RGD uncaging by the magnetic nanoswitch allowed temporal regulation of stem cell adhesion, differentiation, and mechanosensing. This physical and reversible RGD uncaging utilizing heterodimeric magnetic nanoswitch is unprecedented and holds promise in the remote control of cellular behaviors in vivo.

Original languageEnglish
Pages (from-to)5909-5913
Number of pages5
JournalJournal of the American Chemical Society
Volume140
Issue number18
DOIs
Publication statusPublished - 2018 May 9
Externally publishedYes

Fingerprint

Cell adhesion
Remote control
Stem cells
Cell Adhesion
Stem Cells
Adhesion
Behavior Control
Magnetic Fields
Integrins
Gold
Nanoparticles
Peptides
Cell Differentiation
Ligands
Tissue
Magnetic fields
arginyl-glycyl-aspartic acid
In Vitro Techniques

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells. / Kang, Heemin; Jung, Hee Joon; Wong, Dexter Siu Hong; Kim, Sung Kyu; Lin, Sien; Chan, Kai Fung; Zhang, Li; Li, Gang; Dravid, Vinayak P.; Bian, Liming.

In: Journal of the American Chemical Society, Vol. 140, No. 18, 09.05.2018, p. 5909-5913.

Research output: Contribution to journalArticle

Kang, H, Jung, HJ, Wong, DSH, Kim, SK, Lin, S, Chan, KF, Zhang, L, Li, G, Dravid, VP & Bian, L 2018, 'Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells', Journal of the American Chemical Society, vol. 140, no. 18, pp. 5909-5913. https://doi.org/10.1021/jacs.8b03001
Kang, Heemin ; Jung, Hee Joon ; Wong, Dexter Siu Hong ; Kim, Sung Kyu ; Lin, Sien ; Chan, Kai Fung ; Zhang, Li ; Li, Gang ; Dravid, Vinayak P. ; Bian, Liming. / Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells. In: Journal of the American Chemical Society. 2018 ; Vol. 140, No. 18. pp. 5909-5913.
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