Renal capsular invasion is a prognostic biomarker in localized clear cell renal cell carcinoma

U. Syn Ha, Kyu Won Lee, Jin Hyung Jung, Seok Soo Byun, Cheol Kwak, Jinsoo Chung, Eu Chang Hwang, Yong June Kim, Tae Gyun Kwon, Seok Ho Kang, Sung Hoo Hong

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Abstract

Renal capsular invasion (RCI) and lymphovascular invasion (LVI) are potential prognostic factors of significance in renal cell carcinoma (RCC). We evaluated the independent prognostic implications of RCI and LVI in localized clear cell RCC based on a large multi-institutional cohort. 6, 849 patients who had undergone radical or partial nephrectomy for RCC were included. Associations between recurrence and RCI or LVI were analyzed by constructing statistical models that combined Cox proportional hazard regression and propensity score matching. To analyze RCI, 2, 733 patients including 603 patients with RCI were enrolled. To analyze LVI, 3, 586 patients including 121 patients with LVI were enrolled. Recurrence was observed in 75 (12.4%) patients with RCI and 134 (6.3%) patients without RCI. In all statistical models, RCI was significantly associated with an increased risk of recurrence. Recurrence was observed 29 (24.0%) patients with LVI and 207 (6.0%) patients without LVI. LVI was significantly associated with an increased risk of recurrence only in non-adjusted univariate models, but not in multivariate adjusted analysis or propensity score matching models. In conclusion, these findings suggest that RCI could be a significant risk factor for localized clear cell RCC recurrence. In contrast to RCI, LVI cannot be an independent prognostic variable.

Original languageEnglish
Article number202
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Renal Cell Carcinoma
Biomarkers
Kidney
Recurrence
Propensity Score
Statistical Models
Nephrectomy
Multivariate Analysis

ASJC Scopus subject areas

  • General

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Ha, U. S., Lee, K. W., Jung, J. H., Byun, S. S., Kwak, C., Chung, J., ... Hong, S. H. (2018). Renal capsular invasion is a prognostic biomarker in localized clear cell renal cell carcinoma. Scientific Reports, 8(1), [202]. https://doi.org/10.1038/s41598-017-18466-9

Renal capsular invasion is a prognostic biomarker in localized clear cell renal cell carcinoma. / Ha, U. Syn; Lee, Kyu Won; Jung, Jin Hyung; Byun, Seok Soo; Kwak, Cheol; Chung, Jinsoo; Hwang, Eu Chang; Kim, Yong June; Kwon, Tae Gyun; Kang, Seok Ho; Hong, Sung Hoo.

In: Scientific Reports, Vol. 8, No. 1, 202, 01.12.2018.

Research output: Contribution to journalArticle

Ha, US, Lee, KW, Jung, JH, Byun, SS, Kwak, C, Chung, J, Hwang, EC, Kim, YJ, Kwon, TG, Kang, SH & Hong, SH 2018, 'Renal capsular invasion is a prognostic biomarker in localized clear cell renal cell carcinoma', Scientific Reports, vol. 8, no. 1, 202. https://doi.org/10.1038/s41598-017-18466-9
Ha, U. Syn ; Lee, Kyu Won ; Jung, Jin Hyung ; Byun, Seok Soo ; Kwak, Cheol ; Chung, Jinsoo ; Hwang, Eu Chang ; Kim, Yong June ; Kwon, Tae Gyun ; Kang, Seok Ho ; Hong, Sung Hoo. / Renal capsular invasion is a prognostic biomarker in localized clear cell renal cell carcinoma. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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abstract = "Renal capsular invasion (RCI) and lymphovascular invasion (LVI) are potential prognostic factors of significance in renal cell carcinoma (RCC). We evaluated the independent prognostic implications of RCI and LVI in localized clear cell RCC based on a large multi-institutional cohort. 6, 849 patients who had undergone radical or partial nephrectomy for RCC were included. Associations between recurrence and RCI or LVI were analyzed by constructing statistical models that combined Cox proportional hazard regression and propensity score matching. To analyze RCI, 2, 733 patients including 603 patients with RCI were enrolled. To analyze LVI, 3, 586 patients including 121 patients with LVI were enrolled. Recurrence was observed in 75 (12.4{\%}) patients with RCI and 134 (6.3{\%}) patients without RCI. In all statistical models, RCI was significantly associated with an increased risk of recurrence. Recurrence was observed 29 (24.0{\%}) patients with LVI and 207 (6.0{\%}) patients without LVI. LVI was significantly associated with an increased risk of recurrence only in non-adjusted univariate models, but not in multivariate adjusted analysis or propensity score matching models. In conclusion, these findings suggest that RCI could be a significant risk factor for localized clear cell RCC recurrence. In contrast to RCI, LVI cannot be an independent prognostic variable.",
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