Renal function and decline in functional capacity in older adults

Ho J.un Chin, Shin Y.oung Ahn, Jiwon Ryu, Sejoong Kim, Ki Y.oung Na, Ki W.oong Kim, Dong Wan Chae, Cheol Ho Kim, Kwang Il Kim

Research output: Contribution to journalArticle

Abstract

BACKGROUND: longitudinal relationship between renal function, disability and mortality has not been evaluated.

OBJECTIVE: we investigated the temporal association between renal function and disability, and aimed to identify the influence of disability on mortality according to renal function in a cohort of older Koreans.

DESIGN/SETTING: Korean Longitudinal Study on Health and Aging is a prospective, population-based cohort.

SUBJECTS: community-dwelling Koreans ≥65 years of age.

MAIN OUTCOME MEASURES: Korean version of activities of daily living (ADL), Instrumental activities of daily living (IADL) and all-cause mortality.

RESULTS: a total of 984 participants were followed for 5 years with a 70.9% participation rate. The participants were categorized into three groups according to their baseline estimated glomerular filtration rates (eGFRs) (Group I, ≥60; Group II, 45-59; and Group III, <45 ml/min/1.73 m(2)). Baseline eGFR was higher in participants who maintained functional status compared with participants who died or had disability at follow-up examination. The incidence of ADL/IADL decline was 13, 12.5 and 29.5% in participants who showed improvement, no change, and decline in renal function, respectively (P = 0.01). The hazard ratio for mortality in the subgroup with IADL disability was 1.87 (95% CI: 1.10-3.20, P = 0.022) in Group I, and 2.53 (95% CI: 1.57-4.09, P<0.001) in Groups II and III after adjustment.

CONCLUSIONS: impaired renal function was related to disability and ADL/IADL decline. The effect of ADL/IADL disability on mortality was more prominent in participants with impaired eGFR.

Original languageEnglish
Pages (from-to)833-838
Number of pages6
JournalAge and Ageing
Volume43
Issue number6
DOIs
Publication statusPublished - 2014 Nov 1
Externally publishedYes

Fingerprint

Activities of Daily Living
Kidney
Glomerular Filtration Rate
Mortality
Independent Living
Longitudinal Studies

Keywords

  • chronic kidney disease
  • disability
  • mortality
  • older adults
  • older people

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Chin, H. J. U., Ahn, S. Y. O., Ryu, J., Kim, S., Na, K. Y. O., Kim, K. W. O., ... Kim, K. I. (2014). Renal function and decline in functional capacity in older adults. Age and Ageing, 43(6), 833-838. https://doi.org/10.1093/ageing/afu071

Renal function and decline in functional capacity in older adults. / Chin, Ho J.un; Ahn, Shin Y.oung; Ryu, Jiwon; Kim, Sejoong; Na, Ki Y.oung; Kim, Ki W.oong; Chae, Dong Wan; Kim, Cheol Ho; Kim, Kwang Il.

In: Age and Ageing, Vol. 43, No. 6, 01.11.2014, p. 833-838.

Research output: Contribution to journalArticle

Chin, HJU, Ahn, SYO, Ryu, J, Kim, S, Na, KYO, Kim, KWO, Chae, DW, Kim, CH & Kim, KI 2014, 'Renal function and decline in functional capacity in older adults', Age and Ageing, vol. 43, no. 6, pp. 833-838. https://doi.org/10.1093/ageing/afu071
Chin, Ho J.un ; Ahn, Shin Y.oung ; Ryu, Jiwon ; Kim, Sejoong ; Na, Ki Y.oung ; Kim, Ki W.oong ; Chae, Dong Wan ; Kim, Cheol Ho ; Kim, Kwang Il. / Renal function and decline in functional capacity in older adults. In: Age and Ageing. 2014 ; Vol. 43, No. 6. pp. 833-838.
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abstract = "BACKGROUND: longitudinal relationship between renal function, disability and mortality has not been evaluated.OBJECTIVE: we investigated the temporal association between renal function and disability, and aimed to identify the influence of disability on mortality according to renal function in a cohort of older Koreans.DESIGN/SETTING: Korean Longitudinal Study on Health and Aging is a prospective, population-based cohort.SUBJECTS: community-dwelling Koreans ≥65 years of age.MAIN OUTCOME MEASURES: Korean version of activities of daily living (ADL), Instrumental activities of daily living (IADL) and all-cause mortality.RESULTS: a total of 984 participants were followed for 5 years with a 70.9{\%} participation rate. The participants were categorized into three groups according to their baseline estimated glomerular filtration rates (eGFRs) (Group I, ≥60; Group II, 45-59; and Group III, <45 ml/min/1.73 m(2)). Baseline eGFR was higher in participants who maintained functional status compared with participants who died or had disability at follow-up examination. The incidence of ADL/IADL decline was 13, 12.5 and 29.5{\%} in participants who showed improvement, no change, and decline in renal function, respectively (P = 0.01). The hazard ratio for mortality in the subgroup with IADL disability was 1.87 (95{\%} CI: 1.10-3.20, P = 0.022) in Group I, and 2.53 (95{\%} CI: 1.57-4.09, P<0.001) in Groups II and III after adjustment.CONCLUSIONS: impaired renal function was related to disability and ADL/IADL decline. The effect of ADL/IADL disability on mortality was more prominent in participants with impaired eGFR.",
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AU - Chin, Ho J.un

AU - Ahn, Shin Y.oung

AU - Ryu, Jiwon

AU - Kim, Sejoong

AU - Na, Ki Y.oung

AU - Kim, Ki W.oong

AU - Chae, Dong Wan

AU - Kim, Cheol Ho

AU - Kim, Kwang Il

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N2 - BACKGROUND: longitudinal relationship between renal function, disability and mortality has not been evaluated.OBJECTIVE: we investigated the temporal association between renal function and disability, and aimed to identify the influence of disability on mortality according to renal function in a cohort of older Koreans.DESIGN/SETTING: Korean Longitudinal Study on Health and Aging is a prospective, population-based cohort.SUBJECTS: community-dwelling Koreans ≥65 years of age.MAIN OUTCOME MEASURES: Korean version of activities of daily living (ADL), Instrumental activities of daily living (IADL) and all-cause mortality.RESULTS: a total of 984 participants were followed for 5 years with a 70.9% participation rate. The participants were categorized into three groups according to their baseline estimated glomerular filtration rates (eGFRs) (Group I, ≥60; Group II, 45-59; and Group III, <45 ml/min/1.73 m(2)). Baseline eGFR was higher in participants who maintained functional status compared with participants who died or had disability at follow-up examination. The incidence of ADL/IADL decline was 13, 12.5 and 29.5% in participants who showed improvement, no change, and decline in renal function, respectively (P = 0.01). The hazard ratio for mortality in the subgroup with IADL disability was 1.87 (95% CI: 1.10-3.20, P = 0.022) in Group I, and 2.53 (95% CI: 1.57-4.09, P<0.001) in Groups II and III after adjustment.CONCLUSIONS: impaired renal function was related to disability and ADL/IADL decline. The effect of ADL/IADL disability on mortality was more prominent in participants with impaired eGFR.

AB - BACKGROUND: longitudinal relationship between renal function, disability and mortality has not been evaluated.OBJECTIVE: we investigated the temporal association between renal function and disability, and aimed to identify the influence of disability on mortality according to renal function in a cohort of older Koreans.DESIGN/SETTING: Korean Longitudinal Study on Health and Aging is a prospective, population-based cohort.SUBJECTS: community-dwelling Koreans ≥65 years of age.MAIN OUTCOME MEASURES: Korean version of activities of daily living (ADL), Instrumental activities of daily living (IADL) and all-cause mortality.RESULTS: a total of 984 participants were followed for 5 years with a 70.9% participation rate. The participants were categorized into three groups according to their baseline estimated glomerular filtration rates (eGFRs) (Group I, ≥60; Group II, 45-59; and Group III, <45 ml/min/1.73 m(2)). Baseline eGFR was higher in participants who maintained functional status compared with participants who died or had disability at follow-up examination. The incidence of ADL/IADL decline was 13, 12.5 and 29.5% in participants who showed improvement, no change, and decline in renal function, respectively (P = 0.01). The hazard ratio for mortality in the subgroup with IADL disability was 1.87 (95% CI: 1.10-3.20, P = 0.022) in Group I, and 2.53 (95% CI: 1.57-4.09, P<0.001) in Groups II and III after adjustment.CONCLUSIONS: impaired renal function was related to disability and ADL/IADL decline. The effect of ADL/IADL disability on mortality was more prominent in participants with impaired eGFR.

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KW - disability

KW - mortality

KW - older adults

KW - older people

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