Renal function and decline in functional capacityin older adults

Ho Jun chin, Shin Young Ahn, Jiwon ryu, Sejoong Kim, KI Young NA Kim, Dong wan Chae, Cheol Ho kim, Kwang il kim

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Abstract

Background: longitudinal relationship between renal function, disability and mortality has not been evaluated. Objective we investigated the temporal association between renal function and disability, and aimed to identify the influence of disability on mortality according to renal function in a cohort of older Koreans. Design/setting: Korean Longitudinal Study on Health and Aging is a prospective, population-based cohort. Subjects: community-dwelling Koreans ≥65 years of age. Main outcome measures: Korean version of activities of daily living (ADL), Instrumental activities of daily living (IADL) and all-cause mortality. Results: a total of 984 participants were followed for 5 years with a 70.9% participation rate. The participants were categorized into three groups according to their baseline estimated glomerular filtration rates (eGFRs) (Group I, ≥60; Group II, 45-59; and Group III, <45ml/min/1.73 m2). Baseline eGFR was higher in participants who maintained functional status compared with participants who died or had disability at follow-up examination. The incidence of ADL/IADL decline was 13, 12.5 and 29.5% in participants who showed improvement, no change, and decline in renal function, respectively (P = 0.01). The hazard ratio for mortality in the subgroup with IADL disability was 1.87 (95% CI: 1.10-3.20, P = 0.022) in Group I, and 2.53 (95% CI: 1.57-4.09, P<0.001) in Groups II and III after adjustment. Conclusions: impaired renal function was related to disability and ADL/IADL decline. The effect of ADL/IADL disability on mortality was more prominent in participants with impaired eGFR.

Original languageEnglish
Pages (from-to)833-838
Number of pages6
JournalAge and Ageing
Volume43
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

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Keywords

  • Chronic kidney disease
  • Disability
  • Mortality
  • Older adults
  • Older peoplereferences

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

chin, H. J., Ahn, S. Y., ryu, J., Kim, S., Kim, KI. Y. NA., Chae, D. W., kim, C. H., & kim, K. I. (2014). Renal function and decline in functional capacityin older adults. Age and Ageing, 43(6), 833-838. https://doi.org/10.3389/fneur.2014.00246