Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells

Agriculture & Biology

• pregnanes 92%
• nephrotoxicity 88%
• ochratoxin A 81%
• kidney cells 72%
• hydrocarbons 62%
• oxidative stress 53%
• receptors 45%
• proximal tubules 14%
• kidneys 13%
• enzymes 11%
• cells 9%
• heme oxygenase (biliverdin-producing) 8%
• glutamate-cysteine ligase 8%
• oxidoreductases 6%
• quinones 6%
• protein subunits 6%
• NADP (coenzyme) 5%
• cytochrome P-450 5%
• cell viability 5%
• malondialdehyde 5%
• glutathione 5%
• reactive oxygen species 5%

Medicine & Life Sciences

• ochratoxin A 100%
• Pregnane X Receptor 97%
• NF-E2-Related Factor 2 96%
• Aryl Hydrocarbon Receptors 86%
• Oxidative Stress 49%
• Kidney 36%
• Enzymes 13%
• Wounds and Injuries 8%
• Glutamate-Cysteine Ligase 8%
• Cytochrome P-450 CYP1A2 7%
• quinone 7%
• Heme Oxygenase-1 7%
• Cytochrome P-450 CYP3A 6%
• NADP 6%
• Cytochrome P-450 Enzyme System 5%
• Malondialdehyde 5%
• Oxidoreductases 5%
• Glutathione 5%
• Catalytic Domain 5%

Chemical Compounds

• Pregnane 99%
• Ochratoxin A 87%
• Oxidative Stress 67%
• Hydrocarbon 47%
• Nicotinamide 9%
• Dinucleotide 9%
• Cytochrome P450 9%
• Cell Viability 8%
• Reactive Oxygen Metabolite 7%
• Adenine 7%
• Heme 7%
• Glutathione 7%
• Marker 7%
• Cysteine 7%
• Food 6%