Abstract
We examined whether (-)-nicotine infusion can affect kainic acid (KA)-induced neurotoxicity in rats. Although treatment with a single nicotine infusion (0.5 or 1.0 μg/side, i.c.v.) failed to attenuate KA-induced neurotoxicity, repeated nicotine infusions (1.0 μg/side/day for 10 days) attenuated the seizures, the severe loss of cells in hippocampal regions CA1 and CA3, the increase in activator protein (AP)-1 DNA binding activity, and mortality after KA administration. α-Bungarotoxin and mecamylamine blocked the neuroprotective effects of nicotine. These results suggest that repeated nicotine treatment provides α7 nicotinic acetylcholine receptor-mediated neuroprotection against KA toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 292-298 |
| Number of pages | 7 |
| Journal | Epilepsy Research |
| Volume | 73 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 Mar 1 |
| Externally published | Yes |
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Keywords
- α7 nicotinic acetylcholine receptor
- AP-1 DNA binding activity
- Hippocampus
- Kainic acid
- Neuroprotection
- Nicotine
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Neurology
Cite this
Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor. / Shin, Eun J.; Chae, Jong Seok; Jung, Myung E.; Bing, Guoying; Ko, Kwang H.; Kim, Won-Ki; Wie, Myung Bok; Cheon, Mi A.; Nah, Seung Yeol; Kim, Hyoung Chun.
In: Epilepsy Research, Vol. 73, No. 3, 01.03.2007, p. 292-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor
AU - Shin, Eun J.
AU - Chae, Jong Seok
AU - Jung, Myung E.
AU - Bing, Guoying
AU - Ko, Kwang H.
AU - Kim, Won-Ki
AU - Wie, Myung Bok
AU - Cheon, Mi A.
AU - Nah, Seung Yeol
AU - Kim, Hyoung Chun
PY - 2007/3/1
Y1 - 2007/3/1
N2 - We examined whether (-)-nicotine infusion can affect kainic acid (KA)-induced neurotoxicity in rats. Although treatment with a single nicotine infusion (0.5 or 1.0 μg/side, i.c.v.) failed to attenuate KA-induced neurotoxicity, repeated nicotine infusions (1.0 μg/side/day for 10 days) attenuated the seizures, the severe loss of cells in hippocampal regions CA1 and CA3, the increase in activator protein (AP)-1 DNA binding activity, and mortality after KA administration. α-Bungarotoxin and mecamylamine blocked the neuroprotective effects of nicotine. These results suggest that repeated nicotine treatment provides α7 nicotinic acetylcholine receptor-mediated neuroprotection against KA toxicity.
AB - We examined whether (-)-nicotine infusion can affect kainic acid (KA)-induced neurotoxicity in rats. Although treatment with a single nicotine infusion (0.5 or 1.0 μg/side, i.c.v.) failed to attenuate KA-induced neurotoxicity, repeated nicotine infusions (1.0 μg/side/day for 10 days) attenuated the seizures, the severe loss of cells in hippocampal regions CA1 and CA3, the increase in activator protein (AP)-1 DNA binding activity, and mortality after KA administration. α-Bungarotoxin and mecamylamine blocked the neuroprotective effects of nicotine. These results suggest that repeated nicotine treatment provides α7 nicotinic acetylcholine receptor-mediated neuroprotection against KA toxicity.
KW - α7 nicotinic acetylcholine receptor
KW - AP-1 DNA binding activity
KW - Hippocampus
KW - Kainic acid
KW - Neuroprotection
KW - Nicotine
UR - http://www.scopus.com/inward/record.url?scp=33847189602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847189602&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2006.11.004
DO - 10.1016/j.eplepsyres.2006.11.004
M3 - Article
C2 - 17174071
AN - SCOPUS:33847189602
VL - 73
SP - 292
EP - 298
JO - Epilepsy Research
JF - Epilepsy Research
SN - 0920-1211
IS - 3
ER -