Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor

Eun Joo Shin; Jong Seok Chae; Myung Eun Jung; Guoying Bing; Kwang Ho Ko; Won Ki Kim; Myung Bok Wie; Mi Ae Cheon; Seung Yeol Nah; Hyoung Chun Kim

doi:10.1016/j.eplepsyres.2006.11.004

Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor

Eun Joo Shin, Jong Seok Chae, Myung Eun Jung, Guoying Bing, Kwang Ho Ko, Won Ki Kim, Myung Bok Wie, Mi Ae Cheon, Seung Yeol Nah, Hyoung Chun Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

We examined whether (-)-nicotine infusion can affect kainic acid (KA)-induced neurotoxicity in rats. Although treatment with a single nicotine infusion (0.5 or 1.0 μg/side, i.c.v.) failed to attenuate KA-induced neurotoxicity, repeated nicotine infusions (1.0 μg/side/day for 10 days) attenuated the seizures, the severe loss of cells in hippocampal regions CA1 and CA3, the increase in activator protein (AP)-1 DNA binding activity, and mortality after KA administration. α-Bungarotoxin and mecamylamine blocked the neuroprotective effects of nicotine. These results suggest that repeated nicotine treatment provides α7 nicotinic acetylcholine receptor-mediated neuroprotection against KA toxicity.

Original language	English
Pages (from-to)	292-298
Number of pages	7
Journal	Epilepsy Research
Volume	73
Issue number	3
DOIs	https://doi.org/10.1016/j.eplepsyres.2006.11.004
Publication status	Published - 2007 Mar 1

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Keywords

AP-1 DNA binding activity
Hippocampus
Kainic acid
Neuroprotection
Nicotine
α7 nicotinic acetylcholine receptor

ASJC Scopus subject areas

Neurology
Clinical Neurology

Cite this

Shin, E. J., Chae, J. S., Jung, M. E., Bing, G., Ko, K. H., Kim, W. K., Wie, M. B., Cheon, M. A., Nah, S. Y., & Kim, H. C. (2007). Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor. Epilepsy Research, 73(3), 292-298. https://doi.org/10.1016/j.eplepsyres.2006.11.004

Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor. / Shin, Eun Joo; Chae, Jong Seok; Jung, Myung Eun; Bing, Guoying; Ko, Kwang Ho; Kim, Won Ki; Wie, Myung Bok; Cheon, Mi Ae; Nah, Seung Yeol; Kim, Hyoung Chun.

In: Epilepsy Research, Vol. 73, No. 3, 01.03.2007, p. 292-298.

Research output: Contribution to journal › Article

Shin, Eun Joo ; Chae, Jong Seok ; Jung, Myung Eun ; Bing, Guoying ; Ko, Kwang Ho ; Kim, Won Ki ; Wie, Myung Bok ; Cheon, Mi Ae ; Nah, Seung Yeol ; Kim, Hyoung Chun. / Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor. In: Epilepsy Research. 2007 ; Vol. 73, No. 3. pp. 292-298.

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10.1016/j.eplepsyres.2006.11.004