Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor

Eun J. Shin, Jong Seok Chae, Myung E. Jung, Guoying Bing, Kwang H. Ko, Won-Ki Kim, Myung Bok Wie, Mi A. Cheon, Seung Yeol Nah, Hyoung Chun Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We examined whether (-)-nicotine infusion can affect kainic acid (KA)-induced neurotoxicity in rats. Although treatment with a single nicotine infusion (0.5 or 1.0 μg/side, i.c.v.) failed to attenuate KA-induced neurotoxicity, repeated nicotine infusions (1.0 μg/side/day for 10 days) attenuated the seizures, the severe loss of cells in hippocampal regions CA1 and CA3, the increase in activator protein (AP)-1 DNA binding activity, and mortality after KA administration. α-Bungarotoxin and mecamylamine blocked the neuroprotective effects of nicotine. These results suggest that repeated nicotine treatment provides α7 nicotinic acetylcholine receptor-mediated neuroprotection against KA toxicity.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalEpilepsy Research
Volume73
Issue number3
DOIs
Publication statusPublished - 2007 Mar 1
Externally publishedYes

Fingerprint

Intraventricular Infusions
Kainic Acid
Nicotinic Receptors
Nicotine
Hippocampal CA3 Region
Mecamylamine
Hippocampal CA1 Region
Bungarotoxins
Transcription Factor AP-1
Neuroprotective Agents
Seizures
Mortality
DNA
Therapeutics

Keywords

  • α7 nicotinic acetylcholine receptor
  • AP-1 DNA binding activity
  • Hippocampus
  • Kainic acid
  • Neuroprotection
  • Nicotine

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor. / Shin, Eun J.; Chae, Jong Seok; Jung, Myung E.; Bing, Guoying; Ko, Kwang H.; Kim, Won-Ki; Wie, Myung Bok; Cheon, Mi A.; Nah, Seung Yeol; Kim, Hyoung Chun.

In: Epilepsy Research, Vol. 73, No. 3, 01.03.2007, p. 292-298.

Research output: Contribution to journalArticle

Shin, Eun J. ; Chae, Jong Seok ; Jung, Myung E. ; Bing, Guoying ; Ko, Kwang H. ; Kim, Won-Ki ; Wie, Myung Bok ; Cheon, Mi A. ; Nah, Seung Yeol ; Kim, Hyoung Chun. / Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor. In: Epilepsy Research. 2007 ; Vol. 73, No. 3. pp. 292-298.
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