Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor

Eun Joo Shin, Jong Seok Chae, Myung Eun Jung, Guoying Bing, Kwang Ho Ko, Won Ki Kim, Myung Bok Wie, Mi Ae Cheon, Seung Yeol Nah, Hyoung Chun Kim

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We examined whether (-)-nicotine infusion can affect kainic acid (KA)-induced neurotoxicity in rats. Although treatment with a single nicotine infusion (0.5 or 1.0 μg/side, i.c.v.) failed to attenuate KA-induced neurotoxicity, repeated nicotine infusions (1.0 μg/side/day for 10 days) attenuated the seizures, the severe loss of cells in hippocampal regions CA1 and CA3, the increase in activator protein (AP)-1 DNA binding activity, and mortality after KA administration. α-Bungarotoxin and mecamylamine blocked the neuroprotective effects of nicotine. These results suggest that repeated nicotine treatment provides α7 nicotinic acetylcholine receptor-mediated neuroprotection against KA toxicity.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalEpilepsy Research
Issue number3
Publication statusPublished - 2007 Mar 1



  • AP-1 DNA binding activity
  • Hippocampus
  • Kainic acid
  • Neuroprotection
  • Nicotine
  • α7 nicotinic acetylcholine receptor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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