Resins with "Nano-Raisins"

S. Sinha-Ray, Y. Zhang, D. Placke, C. M. Megaridis, Alexander Yarin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Thermosensitive hydrogels are materials which globally shrink/swell in water when the surrounding temperature crosses the lower critical solution temperature (LCST). We demonstrate here a novel class of cross-linked polymeric materials, which do not shrink/swell in water globally, but nevertheless reveal a hydrogel-like, stimuli-responsive behavior. In particular, they demonstate a positive thermosensitive release of the embedded fluorescent dye significantly modulated when temperature crosses the LCST. Using staining with copper, transmission electron microscopy and energy dispersive X-ray analysis, we show that this effect is associated with nanogel "raisins" dispersed in such materials (e.g., polymer nanofibers). Shrinkage of individual nanogel "raisins" at elevated temperatures increases nanoporosity via increased exposure of the existing nanopores to water, or formation of new nanopores/nanocracks in the overstretched polymer matrix in the vicinity of shrinking nanogel "raisins". As a result, the release rate of the embedded dye from the nanofibers increases at elevated temperatures. We suggest that similar functional materials with embedded nanogel "raisins" will find applications in nanofluidics and as drug carriers for controlled drug release.

Original languageEnglish
Pages (from-to)10243-10249
Number of pages7
JournalLangmuir
Volume26
Issue number12
DOIs
Publication statusPublished - 2010 Jun 15
Externally publishedYes

Fingerprint

Vitis
resins
Resins
Temperature
Nanopores
Nanofibers
Hydrogels
temperature
Water
Polymers
drugs
Dyes
dyes
Nanofluidics
water
Drug Carriers
Functional materials
Energy dispersive X ray analysis
Hydrogel
polymers

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy
  • Medicine(all)

Cite this

Sinha-Ray, S., Zhang, Y., Placke, D., Megaridis, C. M., & Yarin, A. (2010). Resins with "Nano-Raisins". Langmuir, 26(12), 10243-10249. https://doi.org/10.1021/la1004177

Resins with "Nano-Raisins". / Sinha-Ray, S.; Zhang, Y.; Placke, D.; Megaridis, C. M.; Yarin, Alexander.

In: Langmuir, Vol. 26, No. 12, 15.06.2010, p. 10243-10249.

Research output: Contribution to journalArticle

Sinha-Ray, S, Zhang, Y, Placke, D, Megaridis, CM & Yarin, A 2010, 'Resins with "Nano-Raisins"', Langmuir, vol. 26, no. 12, pp. 10243-10249. https://doi.org/10.1021/la1004177
Sinha-Ray S, Zhang Y, Placke D, Megaridis CM, Yarin A. Resins with "Nano-Raisins". Langmuir. 2010 Jun 15;26(12):10243-10249. https://doi.org/10.1021/la1004177
Sinha-Ray, S. ; Zhang, Y. ; Placke, D. ; Megaridis, C. M. ; Yarin, Alexander. / Resins with "Nano-Raisins". In: Langmuir. 2010 ; Vol. 26, No. 12. pp. 10243-10249.
@article{e7fd75872f2f480f9857e83c20dccde0,
title = "Resins with {"}Nano-Raisins{"}",
abstract = "Thermosensitive hydrogels are materials which globally shrink/swell in water when the surrounding temperature crosses the lower critical solution temperature (LCST). We demonstrate here a novel class of cross-linked polymeric materials, which do not shrink/swell in water globally, but nevertheless reveal a hydrogel-like, stimuli-responsive behavior. In particular, they demonstate a positive thermosensitive release of the embedded fluorescent dye significantly modulated when temperature crosses the LCST. Using staining with copper, transmission electron microscopy and energy dispersive X-ray analysis, we show that this effect is associated with nanogel {"}raisins{"} dispersed in such materials (e.g., polymer nanofibers). Shrinkage of individual nanogel {"}raisins{"} at elevated temperatures increases nanoporosity via increased exposure of the existing nanopores to water, or formation of new nanopores/nanocracks in the overstretched polymer matrix in the vicinity of shrinking nanogel {"}raisins{"}. As a result, the release rate of the embedded dye from the nanofibers increases at elevated temperatures. We suggest that similar functional materials with embedded nanogel {"}raisins{"} will find applications in nanofluidics and as drug carriers for controlled drug release.",
author = "S. Sinha-Ray and Y. Zhang and D. Placke and Megaridis, {C. M.} and Alexander Yarin",
year = "2010",
month = "6",
day = "15",
doi = "10.1021/la1004177",
language = "English",
volume = "26",
pages = "10243--10249",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - Resins with "Nano-Raisins"

AU - Sinha-Ray, S.

AU - Zhang, Y.

AU - Placke, D.

AU - Megaridis, C. M.

AU - Yarin, Alexander

PY - 2010/6/15

Y1 - 2010/6/15

N2 - Thermosensitive hydrogels are materials which globally shrink/swell in water when the surrounding temperature crosses the lower critical solution temperature (LCST). We demonstrate here a novel class of cross-linked polymeric materials, which do not shrink/swell in water globally, but nevertheless reveal a hydrogel-like, stimuli-responsive behavior. In particular, they demonstate a positive thermosensitive release of the embedded fluorescent dye significantly modulated when temperature crosses the LCST. Using staining with copper, transmission electron microscopy and energy dispersive X-ray analysis, we show that this effect is associated with nanogel "raisins" dispersed in such materials (e.g., polymer nanofibers). Shrinkage of individual nanogel "raisins" at elevated temperatures increases nanoporosity via increased exposure of the existing nanopores to water, or formation of new nanopores/nanocracks in the overstretched polymer matrix in the vicinity of shrinking nanogel "raisins". As a result, the release rate of the embedded dye from the nanofibers increases at elevated temperatures. We suggest that similar functional materials with embedded nanogel "raisins" will find applications in nanofluidics and as drug carriers for controlled drug release.

AB - Thermosensitive hydrogels are materials which globally shrink/swell in water when the surrounding temperature crosses the lower critical solution temperature (LCST). We demonstrate here a novel class of cross-linked polymeric materials, which do not shrink/swell in water globally, but nevertheless reveal a hydrogel-like, stimuli-responsive behavior. In particular, they demonstate a positive thermosensitive release of the embedded fluorescent dye significantly modulated when temperature crosses the LCST. Using staining with copper, transmission electron microscopy and energy dispersive X-ray analysis, we show that this effect is associated with nanogel "raisins" dispersed in such materials (e.g., polymer nanofibers). Shrinkage of individual nanogel "raisins" at elevated temperatures increases nanoporosity via increased exposure of the existing nanopores to water, or formation of new nanopores/nanocracks in the overstretched polymer matrix in the vicinity of shrinking nanogel "raisins". As a result, the release rate of the embedded dye from the nanofibers increases at elevated temperatures. We suggest that similar functional materials with embedded nanogel "raisins" will find applications in nanofluidics and as drug carriers for controlled drug release.

UR - http://www.scopus.com/inward/record.url?scp=77956070249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956070249&partnerID=8YFLogxK

U2 - 10.1021/la1004177

DO - 10.1021/la1004177

M3 - Article

C2 - 20151666

AN - SCOPUS:77956070249

VL - 26

SP - 10243

EP - 10249

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 12

ER -