Resolution enhancement of diffusion-weighted images by local fiber profiling

Pew Thian Yap, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Diffusion-weighted imaging (DWI), while giving rich information about brain circuitry, is often limited by insufficient spatial resolution and low signal-to-noise ratio (SNR). This paper describes an algorithm that will increase the resolution of DW images beyond the scan resolution, allowing for a closer investigation of fiber structures and more accurate assessment of brain connectivity. The algorithm is capable of generating a dense vector-valued field, consisting of diffusion data associated with the full set of diffusion-sensitizing gradients. The fundamental premise is that, to best preserve information, interpolation should always be performed along fiber streamlines. To achieve this, at each spatial location, we probe neighboring voxels in various directions to gather diffusion information for data reconstruction. Based on the fiber orientation distribution (FOD), directions that are more likely to be traversed by fibers will be given greater weights during interpolation and vice versa. This ensures that data reconstruction is only contributed by diffusion data coming from fibers that are aligned with a specific direction. This approach respects local fiber structures and prevents blurring resulting from averaging of data from significantly misaligned fibers. Evaluations suggest that this algorithm yields results with significantly less blocking artifacts, greater smoothness in anatomical structures, and markedly improved structural visibility.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings
EditorsNicholas Ayache, Herve Delingette, Polina Golland, Kensaku Mori
PublisherSpringer Verlag
Pages18-25
Number of pages8
ISBN (Print)9783642334535
DOIs
Publication statusPublished - 2012
Event15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012 - Nice, France
Duration: 2012 Oct 12012 Oct 5

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7512 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012
CountryFrance
CityNice
Period12/10/112/10/5

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Fingerprint Dive into the research topics of 'Resolution enhancement of diffusion-weighted images by local fiber profiling'. Together they form a unique fingerprint.

  • Cite this

    Yap, P. T., & Shen, D. (2012). Resolution enhancement of diffusion-weighted images by local fiber profiling. In N. Ayache, H. Delingette, P. Golland, & K. Mori (Eds.), Medical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings (pp. 18-25). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7512 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-642-33454-2_3