Resolution of pregabalin and mirtazapine associated restless legs syndrome by bupropion in a patient with major depressive disorder

Young Min Park, Heon Jeong Lee, Seung Gul Kang, Jae Hyuck Cho, Leen Kim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Bupropion is a selective norepinephrine and dopamine reuptake inhibitor with no serotonergic activity, and is therefore an antidepressant with unique pharmacological properties. There are some reports that selective serotonin reuptake inhibitors (SSRIs) or mirtazapine can induce adverse effects including restless legs syndrome (RLS) and that bupropion can reverse these adverse effects. Here, we report about a patient with a major depressive disorder who exhibited RLS after being treated with pregabalin and mirtazapine. This adverse effect disappeared after having switched from mirtazapine to bupropion. Bupropion inhibits the reuptake of dopamine and increases dopamine neurotransmission in both the nucleus accumbens and the prefrontal cortex. This pharmacological profile can be effective in patients with RLS related to dopamine hypoactivity. However, the limitations of this single case report mean that further investigations with larger samples are needed.

Original languageEnglish
Pages (from-to)313-315
Number of pages3
JournalPsychiatry Investigation
Volume6
Issue number4
DOIs
Publication statusPublished - 2009 Dec

Keywords

  • Bupropion
  • Mirtazapine
  • Pregabalin
  • Restless legs syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Resolution of pregabalin and mirtazapine associated restless legs syndrome by bupropion in a patient with major depressive disorder'. Together they form a unique fingerprint.

Cite this