Resolving m6A epitranscriptome with stoichiometry

Ki Jun Yoon, Yoon Ki Kim

Research output: Contribution to journalShort surveypeer-review

Abstract

A recent study by Hu et al. describes N6-methyladenosine (m6A)-selective allyl chemical labeling and sequencing (m6A-SAC-seq), which allows for quantitative, stoichiometric, and positional analyses of m6A at single-nucleotide resolution across the whole transcriptome level. Information on the m6A stoichiometry will provide additional layers of gene regulatory pathways mediated by m6A modification during diverse molecular, cellular, and physiological events.

Original languageEnglish
Pages (from-to)1099-1100
Number of pages2
JournalTrends in Genetics
Volume38
Issue number11
DOIs
Publication statusPublished - 2022 Nov

Keywords

  • chemical-assisted sequencing
  • mA modification
  • mA-SAC-seq
  • quantitative analysis
  • stoichiometry

ASJC Scopus subject areas

  • Genetics

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