Abstract
A response surface methodology was used to build a model to predict reductions in uropathogenic Escherichia coli biofilms in response to three compounds: cranberry extract [CB] at 3.0–9.0%, and caprylic acid [CAR] and thymol [TM] at 0.01%–0.05%. The predictive model for microbial reduction had a high regression coefficient (R2 = 0.9988), and the accuracy of the model was verified (R2 = 0.9527). Values of CAR, TM, and the quadratic term CAR2 were the most significant (P < 0.0001) for bacterial reduction. Interactions between CB and CAR, and TM and CB, also affected bacterial reduction. The optimum conditions (a 5.8 log10 reduction) determined by ridge analysis were 8.3% CB +0.04% CAR +0.04% TM at 37 °C for 1 min. The model could be used to predict the most cost-efficient amounts of antimicrobial agents for anti-urinary tract infection products such as catheter lock solution and antimicrobial coatings for catheters.
| Original language | English |
|---|---|
| Journal | Biofouling |
| DOIs | |
| Publication status | Accepted/In press - 2018 Jan 1 |
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Keywords
- Antimicrobial mixtures
- biofilm eradication; Escherichia coli
- natural products
- optimization modeling
- uropathogenic
ASJC Scopus subject areas
- Aquatic Science
- Applied Microbiology and Biotechnology
- Water Science and Technology
Cite this
Response surface modeling of reductions in uropathogenic Escherichia coli biofilms on silicone by cranberry extract, caprylic acid, and thymol. / Kim, Hye Won; Rhee, Min-Suk.
In: Biofouling, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Response surface modeling of reductions in uropathogenic Escherichia coli biofilms on silicone by cranberry extract, caprylic acid, and thymol
AU - Kim, Hye Won
AU - Rhee, Min-Suk
PY - 2018/1/1
Y1 - 2018/1/1
N2 - A response surface methodology was used to build a model to predict reductions in uropathogenic Escherichia coli biofilms in response to three compounds: cranberry extract [CB] at 3.0–9.0%, and caprylic acid [CAR] and thymol [TM] at 0.01%–0.05%. The predictive model for microbial reduction had a high regression coefficient (R2 = 0.9988), and the accuracy of the model was verified (R2 = 0.9527). Values of CAR, TM, and the quadratic term CAR2 were the most significant (P < 0.0001) for bacterial reduction. Interactions between CB and CAR, and TM and CB, also affected bacterial reduction. The optimum conditions (a 5.8 log10 reduction) determined by ridge analysis were 8.3% CB +0.04% CAR +0.04% TM at 37 °C for 1 min. The model could be used to predict the most cost-efficient amounts of antimicrobial agents for anti-urinary tract infection products such as catheter lock solution and antimicrobial coatings for catheters.
AB - A response surface methodology was used to build a model to predict reductions in uropathogenic Escherichia coli biofilms in response to three compounds: cranberry extract [CB] at 3.0–9.0%, and caprylic acid [CAR] and thymol [TM] at 0.01%–0.05%. The predictive model for microbial reduction had a high regression coefficient (R2 = 0.9988), and the accuracy of the model was verified (R2 = 0.9527). Values of CAR, TM, and the quadratic term CAR2 were the most significant (P < 0.0001) for bacterial reduction. Interactions between CB and CAR, and TM and CB, also affected bacterial reduction. The optimum conditions (a 5.8 log10 reduction) determined by ridge analysis were 8.3% CB +0.04% CAR +0.04% TM at 37 °C for 1 min. The model could be used to predict the most cost-efficient amounts of antimicrobial agents for anti-urinary tract infection products such as catheter lock solution and antimicrobial coatings for catheters.
KW - Antimicrobial mixtures
KW - biofilm eradication; Escherichia coli
KW - natural products
KW - optimization modeling
KW - uropathogenic
UR - http://www.scopus.com/inward/record.url?scp=85053238062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053238062&partnerID=8YFLogxK
U2 - 10.1080/08927014.2018.1488969
DO - 10.1080/08927014.2018.1488969
M3 - Article
C2 - 30187778
AN - SCOPUS:85053238062
JO - Biofouling
JF - Biofouling
SN - 0892-7014
ER -