Resting-state functional connectivity in medication-naïve adolescents with major depressive disorder

Jeonho Lee, Mani N. Pavuluri, Ji Hyun Kim, Sangil Suh, Inseong Kim, Moon Soo Lee

Research output: Contribution to journalArticle

Abstract

Adolescence is a vulnerable period for major depressive disorder (MDD). The aim of our study was to investigate resting-state functional connectivity (RSFC) in first-episode, medication-naïve adolescent MDD patients. Twenty-three drug-naïve adolescents diagnosed with first-episode MDD and 27 healthy participants were enrolled. Seed-to-voxel RSFC analyses were performed. The frontolimbic circuit regions of interest included the amygdala, anterior cingulate cortex, insula, and hippocampus. A correlation analysis between the RSFC and Children's Depression Inventory, Hamilton depression rating scale, and duration of episodes was performed. The adolescents with MDD exhibited the following characteristics: a lower RSFC between the right amygdala and right superior frontal gyrus; a lower RSFC between the right hippocampus and clusters including the right insula and right middle frontal gyrus; a higher RSFC between the left insula and clusters including the bilateral middle frontal gyrus, right superior frontal gyrus, and right frontal pole; and a higher RSFC between the left dorsal anterior cingulate cortex and a cluster including the left insula. Medication-naïve adolescents with depression display lower connectivity of several brain regions implicated in processing, regulation, and memory of emotions. Higher connectivity was observed in brain regions that potentially explain rumination, impaired concentration, and physiological arousal.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume288
DOIs
Publication statusPublished - 2019 Jun 30

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Major Depressive Disorder
Gyrus Cinguli
Depression
Amygdala
Prefrontal Cortex
Hippocampus
Brain
Arousal
Seeds
Healthy Volunteers
Emotions
Equipment and Supplies
Pharmaceutical Preparations

Keywords

  • Amygdala
  • Conn
  • Depression
  • First-onset
  • Hippocampus
  • Insula
  • Seed-to-voxel

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Resting-state functional connectivity in medication-naïve adolescents with major depressive disorder. / Lee, Jeonho; Pavuluri, Mani N.; Kim, Ji Hyun; Suh, Sangil; Kim, Inseong; Lee, Moon Soo.

In: Psychiatry Research - Neuroimaging, Vol. 288, 30.06.2019, p. 37-43.

Research output: Contribution to journalArticle

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