Abstract
Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREscontaining mRNAs such as proto-oncogenes, antiapoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4′-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3′ untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.
| Original language | English |
|---|---|
| Pages (from-to) | 991-997 |
| Number of pages | 7 |
| Journal | Molecules and cells |
| Volume | 38 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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Keywords
- Apoptosis
- Glioma
- Resveratrol
- TTP
- uPA
- uPAR
ASJC Scopus subject areas
- Medicine(all)
Cite this
Resveratrol induces glioma cell apoptosis through activation of tristetraprolin. / Ryu, Jinhyun; Yoon, Nal Ae; Seong, Hyemin; Jeong, Joo Yeon; Kang, Seokmin; Park, Nammi; Choi, Jungil; Lee, Dong Hoon; Roh, Gu Seob; Kim, Hyun Joon; Cho, Gyeong Jae; Choi, Wan Sung; Park, Jae-Yong; Park, Jeong Woo; Kang, Sang Soo.
In: Molecules and cells, Vol. 38, No. 11, 01.01.2015, p. 991-997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Resveratrol induces glioma cell apoptosis through activation of tristetraprolin
AU - Ryu, Jinhyun
AU - Yoon, Nal Ae
AU - Seong, Hyemin
AU - Jeong, Joo Yeon
AU - Kang, Seokmin
AU - Park, Nammi
AU - Choi, Jungil
AU - Lee, Dong Hoon
AU - Roh, Gu Seob
AU - Kim, Hyun Joon
AU - Cho, Gyeong Jae
AU - Choi, Wan Sung
AU - Park, Jae-Yong
AU - Park, Jeong Woo
AU - Kang, Sang Soo
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREscontaining mRNAs such as proto-oncogenes, antiapoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4′-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3′ untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.
AB - Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREscontaining mRNAs such as proto-oncogenes, antiapoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4′-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3′ untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.
KW - Apoptosis
KW - Glioma
KW - Resveratrol
KW - TTP
KW - uPA
KW - uPAR
UR - http://www.scopus.com/inward/record.url?scp=84975260027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975260027&partnerID=8YFLogxK
U2 - 10.14348/molcells.2015.0197
DO - 10.14348/molcells.2015.0197
M3 - Article
C2 - 26537190
AN - SCOPUS:84975260027
VL - 38
SP - 991
EP - 997
JO - Molecules and Cells
JF - Molecules and Cells
SN - 1016-8478
IS - 11
ER -