Resveratrol induces glioma cell apoptosis through activation of tristetraprolin

Jinhyun Ryu, Nal Ae Yoon, Hyemin Seong, Joo Yeon Jeong, Seokmin Kang, Nammi Park, Jungil Choi, Dong Hoon Lee, Gu Seob Roh, Hyun Joon Kim, Gyeong Jae Cho, Wan Sung Choi, Jae-Yong Park, Jeong Woo Park, Sang Soo Kang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREscontaining mRNAs such as proto-oncogenes, antiapoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4′-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3′ untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.

Original languageEnglish
Pages (from-to)991-997
Number of pages7
JournalMolecules and cells
Volume38
Issue number11
DOIs
Publication statusPublished - 2015 Jan 1

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Keywords

  • Apoptosis
  • Glioma
  • Resveratrol
  • TTP
  • uPA
  • uPAR

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ryu, J., Yoon, N. A., Seong, H., Jeong, J. Y., Kang, S., Park, N., Choi, J., Lee, D. H., Roh, G. S., Kim, H. J., Cho, G. J., Choi, W. S., Park, J-Y., Park, J. W., & Kang, S. S. (2015). Resveratrol induces glioma cell apoptosis through activation of tristetraprolin. Molecules and cells, 38(11), 991-997. https://doi.org/10.14348/molcells.2015.0197