Retinoic acid modulates the level of nerve growth factor gene expression and proliferation of cultured human keratinocytes

Jin Woo Lee, Yong Kwon Lee, Bok Hwan Chun, Mu Hyoung Lee, Won Gi Bang, Young Woo Jin, Nahmhyun Chung

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Abstract

Retinoic acid (RA) inhibited proliferation of cultured human keratinocytes. Southern blot analysis at 24 h showed that RA inhibited nerve growth factor (NGF) mRNA synthesis in a dose-dependent manner. However, RA stimulated the production of NGF protein up to 187% of control after 96 h and the treatment of cells with RA did not enhance apoptosis, either in the presence of low or high concentration of Ca2+, when compared to the control with DMSO.

Original languageEnglish
Pages (from-to)2035-2040
Number of pages6
JournalBiotechnology letters
Volume24
Issue number24
DOIs
Publication statusPublished - 2002 Dec 1

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Keywords

  • Apoptosis
  • Keratinocyte
  • Nerve growth factor
  • Proliferation
  • Retinoic acid

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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