Retraction: AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells (Journal of Biological Chemistry (2003) 278 (39653–39661) DOI: 10.1074/jbc.M306104200)

Minyoung Lee, Jin Taek Hwang, Hye Jeong Lee, Seung Nam Jung, Insug Kang, Sung Gil Chi, Sung Soo Kim, Joohun Ha

Research output: Contribution to journalComment/debatepeer-review

1 Citation (Scopus)

Abstract

This article has been withdrawn by the authors. In Fig. 1B, lanes 1-2 and lanes 3- 4 of the ACC immunoblot on the right were duplicated. The first lane of the pACC immunoblot on the right in Fig. 1B was duplicated in Fig. 2A. The HIF-1a immunoblot on the left in Fig. 1B was reused in Fig. 8A. The pACC and ACC immunoblots in Fig. 2A contained duplicated bands. The VEGF and Glut1 gels in Fig. 3 contained duplicated bands. The HIF-1a and tubulin immunoblots in Fig. 6A had duplicated bands. In Fig. 6B, lanes 3 and 7 of the pACC immunoblot were duplicated. In Fig. 8A, a lighter exposure of the first lane was pasted on top of the pACC immunoblot. Additionally, the pJNK immunoblot contained more than 8 lanes of data. Also in Fig. 8A, lanes 1- 4 of the ERK immunoblot were duplicated in lanes 5- 8. Lanes 1-3 of the pp38 immunoblot were duplicated in lanes 4- 6 in Fig. 8A. In Fig. 8C, the last two lanes of the HIF-1ß immunoblot were duplicated. The Journal also raised questions regarding the pERK immunoblot in Fig. 8A, which the authors were unable to address. Because the original data are no longer available, the authors state that they repeated the above-mentioned experiments and obtained essentially identical results. The authors state that they have full confidence in the conclusions of this paper. The authors apologize to the readers.

Original languageEnglish
Pages (from-to)18013
Number of pages1
JournalJournal of Biological Chemistry
Volume293
Issue number46
DOIs
Publication statusPublished - 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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