Abstract
Background: Aggravated melasma after treatment is vulnerable to stimulation, can easily deteriorate, and may be distressing without proper management. Objective: To retrospectively assess the effectiveness and safety of combination therapy using low-fluence Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (QSNY) and long-pulse Nd:YAG laser (LPNY) (dual toning) in patients with rebound melasma. Materials and methods: A total of 30 patients with aggravated melasma after previous therapy who were treated with dual toning were enrolled. A total of 10 sessions were conducted at 1-week intervals, followed by maintenance treatment. The results were evaluated using the modified Melasma Area and Severity Index (mMASI) and the physician's global assessment (PGA) before and 2 months after completing the 10 treatment sessions. Results: The baseline mMASI was 10.48 ± 3.64, which significantly decreased to 3.22 ± 1.45 2 months after completing the 10 treatment sessions (p < 0.001). Twenty-four patients (80%) had PGA grade 4 (76-100% improvement) and 6 patients (20%) had PGA grade 3 (51-75% improvement). Conclusion: Dual toning may be a safe and effective salvage treatment for patients with aggravated melasma after previous treatment. LPNY may stabilize melasma activity to prevent rebound hyperpigmentation via dermal remodeling.
| Original language | English |
|---|---|
| Pages (from-to) | 129-134 |
| Number of pages | 6 |
| Journal | Journal of Cosmetic and Laser Therapy |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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Keywords
- Adverse events
- Long-pulsed Nd:YAG laser
- Melasma
- Q-switched Nd:YAG laser
- Rebound hyperpigmentation
ASJC Scopus subject areas
- Surgery
- Dermatology
Cite this
Retreatment using a dual mode of low-fluence Q-switched and long-pulse Nd : YAG laser in patients with melasma aggravation after previous therapy. / Choi, Chun Pil; Yim, Seon Mi; Seo, Soo-Hong; Ahn, Hyo Hyun; Kye, Young Chul; Choi, Jae Eun.
In: Journal of Cosmetic and Laser Therapy, Vol. 17, No. 3, 01.01.2015, p. 129-134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retreatment using a dual mode of low-fluence Q-switched and long-pulse Nd
T2 - YAG laser in patients with melasma aggravation after previous therapy
AU - Choi, Chun Pil
AU - Yim, Seon Mi
AU - Seo, Soo-Hong
AU - Ahn, Hyo Hyun
AU - Kye, Young Chul
AU - Choi, Jae Eun
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: Aggravated melasma after treatment is vulnerable to stimulation, can easily deteriorate, and may be distressing without proper management. Objective: To retrospectively assess the effectiveness and safety of combination therapy using low-fluence Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (QSNY) and long-pulse Nd:YAG laser (LPNY) (dual toning) in patients with rebound melasma. Materials and methods: A total of 30 patients with aggravated melasma after previous therapy who were treated with dual toning were enrolled. A total of 10 sessions were conducted at 1-week intervals, followed by maintenance treatment. The results were evaluated using the modified Melasma Area and Severity Index (mMASI) and the physician's global assessment (PGA) before and 2 months after completing the 10 treatment sessions. Results: The baseline mMASI was 10.48 ± 3.64, which significantly decreased to 3.22 ± 1.45 2 months after completing the 10 treatment sessions (p < 0.001). Twenty-four patients (80%) had PGA grade 4 (76-100% improvement) and 6 patients (20%) had PGA grade 3 (51-75% improvement). Conclusion: Dual toning may be a safe and effective salvage treatment for patients with aggravated melasma after previous treatment. LPNY may stabilize melasma activity to prevent rebound hyperpigmentation via dermal remodeling.
AB - Background: Aggravated melasma after treatment is vulnerable to stimulation, can easily deteriorate, and may be distressing without proper management. Objective: To retrospectively assess the effectiveness and safety of combination therapy using low-fluence Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (QSNY) and long-pulse Nd:YAG laser (LPNY) (dual toning) in patients with rebound melasma. Materials and methods: A total of 30 patients with aggravated melasma after previous therapy who were treated with dual toning were enrolled. A total of 10 sessions were conducted at 1-week intervals, followed by maintenance treatment. The results were evaluated using the modified Melasma Area and Severity Index (mMASI) and the physician's global assessment (PGA) before and 2 months after completing the 10 treatment sessions. Results: The baseline mMASI was 10.48 ± 3.64, which significantly decreased to 3.22 ± 1.45 2 months after completing the 10 treatment sessions (p < 0.001). Twenty-four patients (80%) had PGA grade 4 (76-100% improvement) and 6 patients (20%) had PGA grade 3 (51-75% improvement). Conclusion: Dual toning may be a safe and effective salvage treatment for patients with aggravated melasma after previous treatment. LPNY may stabilize melasma activity to prevent rebound hyperpigmentation via dermal remodeling.
KW - Adverse events
KW - Long-pulsed Nd:YAG laser
KW - Melasma
KW - Q-switched Nd:YAG laser
KW - Rebound hyperpigmentation
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U2 - 10.3109/14764172.2014.988730
DO - 10.3109/14764172.2014.988730
M3 - Article
VL - 17
SP - 129
EP - 134
JO - Journal of Cosmetic and Laser Therapy
JF - Journal of Cosmetic and Laser Therapy
SN - 1476-4172
IS - 3
ER -