Retrospective analysis of melasma treatment using a dual mode of low-fluence Q-switched and long-pulse Nd: YAG laser vs. low-fluence Q-switched Nd:YAG laser monotherapy

Chun Pil Choi, Seon Mi Yim, Soo-Hong Seo, Hyo Hyun Ahn, Young Chul Kye, Jae Eun Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Despite the effectiveness of low-fluence Q-switched Nd:YAG laser (QSNY) treatment in melasma, adverse events, including mottled hypopigmentation (MH) and rebound hyperpigmentation (RH) have been reported. Objective: To compare the effectiveness and safety of combination therapy using low-fluence QSNY and long-pulse Nd:YAG laser (LPNY) (Dual toning), with low-fluence QSNY monotherapy (QS toning), in Asian melasma patients. Materials and methods: Patients were treated for 10 sessions at 1-week intervals with QSNY (6 mm spot); 2.5-3.0 J/cm for QS toning (n = 177) or 2.1-2.5 J/cm for dual toning (n = 183). The dual toning group was immediately treated with LPNY (7 mm spot, 15-17 J/cm). The results were evaluated using the modified Melasma Area and Severity Index (mMASI) score and the physician's global assessment. Results: MH or RH were significantly lower (1.1% vs. 14.1%) and the treatment efficacy was improved (median decrease of mMASI, 3.6 vs. 3.0) in the dual toning group compared with the QS toning group. Periorbital melasma showed distinctively high rates of adverse events in the QS toning group (23.9% vs. 5.7%), which were significantly reduced in the dual toning group (2.9%). Conclusion: Dual toning could represent a safe and effective treatment for Asian melasma patients, as it is associated with minimal adverse events and improved treatment efficacy compared with QS toning monotherapy.

Original languageEnglish
Pages (from-to)2-8
Number of pages7
JournalJournal of Cosmetic and Laser Therapy
Volume17
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Melanosis
Solid-State Lasers
Hypopigmentation
Hyperpigmentation
Therapeutics
Physicians
Safety

Keywords

  • Long-pulse Nd:YAG laser
  • Melasma
  • Mottled hypopigmentation
  • Q-switched Nd:YAG laser
  • Rebound hyperpigmentation

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

@article{2b0ddc755dfe4b1a9f2faa61ca5bec79,
title = "Retrospective analysis of melasma treatment using a dual mode of low-fluence Q-switched and long-pulse Nd: YAG laser vs. low-fluence Q-switched Nd:YAG laser monotherapy",
abstract = "Background: Despite the effectiveness of low-fluence Q-switched Nd:YAG laser (QSNY) treatment in melasma, adverse events, including mottled hypopigmentation (MH) and rebound hyperpigmentation (RH) have been reported. Objective: To compare the effectiveness and safety of combination therapy using low-fluence QSNY and long-pulse Nd:YAG laser (LPNY) (Dual toning), with low-fluence QSNY monotherapy (QS toning), in Asian melasma patients. Materials and methods: Patients were treated for 10 sessions at 1-week intervals with QSNY (6 mm spot); 2.5-3.0 J/cm for QS toning (n = 177) or 2.1-2.5 J/cm for dual toning (n = 183). The dual toning group was immediately treated with LPNY (7 mm spot, 15-17 J/cm). The results were evaluated using the modified Melasma Area and Severity Index (mMASI) score and the physician's global assessment. Results: MH or RH were significantly lower (1.1{\%} vs. 14.1{\%}) and the treatment efficacy was improved (median decrease of mMASI, 3.6 vs. 3.0) in the dual toning group compared with the QS toning group. Periorbital melasma showed distinctively high rates of adverse events in the QS toning group (23.9{\%} vs. 5.7{\%}), which were significantly reduced in the dual toning group (2.9{\%}). Conclusion: Dual toning could represent a safe and effective treatment for Asian melasma patients, as it is associated with minimal adverse events and improved treatment efficacy compared with QS toning monotherapy.",
keywords = "Long-pulse Nd:YAG laser, Melasma, Mottled hypopigmentation, Q-switched Nd:YAG laser, Rebound hyperpigmentation",
author = "Choi, {Chun Pil} and Yim, {Seon Mi} and Soo-Hong Seo and Ahn, {Hyo Hyun} and Kye, {Young Chul} and Choi, {Jae Eun}",
year = "2015",
month = "1",
day = "1",
doi = "10.3109/14764172.2014.957217",
language = "English",
volume = "17",
pages = "2--8",
journal = "Journal of Cosmetic and Laser Therapy",
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TY - JOUR

T1 - Retrospective analysis of melasma treatment using a dual mode of low-fluence Q-switched and long-pulse Nd

T2 - YAG laser vs. low-fluence Q-switched Nd:YAG laser monotherapy

AU - Choi, Chun Pil

AU - Yim, Seon Mi

AU - Seo, Soo-Hong

AU - Ahn, Hyo Hyun

AU - Kye, Young Chul

AU - Choi, Jae Eun

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Despite the effectiveness of low-fluence Q-switched Nd:YAG laser (QSNY) treatment in melasma, adverse events, including mottled hypopigmentation (MH) and rebound hyperpigmentation (RH) have been reported. Objective: To compare the effectiveness and safety of combination therapy using low-fluence QSNY and long-pulse Nd:YAG laser (LPNY) (Dual toning), with low-fluence QSNY monotherapy (QS toning), in Asian melasma patients. Materials and methods: Patients were treated for 10 sessions at 1-week intervals with QSNY (6 mm spot); 2.5-3.0 J/cm for QS toning (n = 177) or 2.1-2.5 J/cm for dual toning (n = 183). The dual toning group was immediately treated with LPNY (7 mm spot, 15-17 J/cm). The results were evaluated using the modified Melasma Area and Severity Index (mMASI) score and the physician's global assessment. Results: MH or RH were significantly lower (1.1% vs. 14.1%) and the treatment efficacy was improved (median decrease of mMASI, 3.6 vs. 3.0) in the dual toning group compared with the QS toning group. Periorbital melasma showed distinctively high rates of adverse events in the QS toning group (23.9% vs. 5.7%), which were significantly reduced in the dual toning group (2.9%). Conclusion: Dual toning could represent a safe and effective treatment for Asian melasma patients, as it is associated with minimal adverse events and improved treatment efficacy compared with QS toning monotherapy.

AB - Background: Despite the effectiveness of low-fluence Q-switched Nd:YAG laser (QSNY) treatment in melasma, adverse events, including mottled hypopigmentation (MH) and rebound hyperpigmentation (RH) have been reported. Objective: To compare the effectiveness and safety of combination therapy using low-fluence QSNY and long-pulse Nd:YAG laser (LPNY) (Dual toning), with low-fluence QSNY monotherapy (QS toning), in Asian melasma patients. Materials and methods: Patients were treated for 10 sessions at 1-week intervals with QSNY (6 mm spot); 2.5-3.0 J/cm for QS toning (n = 177) or 2.1-2.5 J/cm for dual toning (n = 183). The dual toning group was immediately treated with LPNY (7 mm spot, 15-17 J/cm). The results were evaluated using the modified Melasma Area and Severity Index (mMASI) score and the physician's global assessment. Results: MH or RH were significantly lower (1.1% vs. 14.1%) and the treatment efficacy was improved (median decrease of mMASI, 3.6 vs. 3.0) in the dual toning group compared with the QS toning group. Periorbital melasma showed distinctively high rates of adverse events in the QS toning group (23.9% vs. 5.7%), which were significantly reduced in the dual toning group (2.9%). Conclusion: Dual toning could represent a safe and effective treatment for Asian melasma patients, as it is associated with minimal adverse events and improved treatment efficacy compared with QS toning monotherapy.

KW - Long-pulse Nd:YAG laser

KW - Melasma

KW - Mottled hypopigmentation

KW - Q-switched Nd:YAG laser

KW - Rebound hyperpigmentation

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