Reversible splenial abnormality in hypoglycemic encephalopathy

Research output: Contribution to journalArticle

46 Citations (Scopus)


Introduction: Lesions involving the splenium of the corpus callosum (SCC) have been rarely reported in cases of hypoglycemic brain injury. Methods: We identified signal abnormalities in the SCC in three adult patients with hypoglycemic encephalopathy by using diffusion-weighted imaging (DWI) on a 1.5-T MR scanner. Repeat DWI was performed in all patients following a marked clinical improvement, and MR angiography and routine MRI were also performed. We examined each patient's detailed medical history and blood laboratory tests in order to exclude other conditions causing similar SCC abnormalities. Results: Initial DWI was performed during which each patient showed altered mental status that was attributed to profound hypoglycemia. We observed an identical pattern of DWI abnormality characterized by high signals in the SCC with apparent diffusion coefficient reductions that were reversed completely within several days following appropriate correction of hypoglycemia. T2-weighted or FLAIR images also showed no residual lesion in the SCC and MR angiography was normal in all patients. Conclusion: These case reports suggest that the SCC should beadded to the list of selective vulnerability to hypoglycemia and that hypoglycemia, in turn, be included in the differential diagnosis of reversible SCC abnormalities.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
Issue number3
Publication statusPublished - 2007 Mar


  • Diffusion-weighted imaging (DWI)
  • Hypoglycemia
  • Splenium

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Reversible splenial abnormality in hypoglycemic encephalopathy'. Together they form a unique fingerprint.

  • Cite this