Review of 67 patients with autoimmune pancreatitis in korea: A multicenter nationwide study

Ji Kon Ryu, Jae Bock Chung, Seung Woo Park, Jong Kyun Lee, Kyu Tack Lee, Woo Jin Lee, Jong Ho Moon, Kwang Bum Cho, Dae Whan Kang, Jin Hyeok Hwang, Kyo Sang Yoo, Byung Moo Yoo, Don Hang Lee, Hae Kyung Kim, Young Soo Moon, Jin Lee, Hong Sik Lee, Ho Sun Choi, Sung Koo Lee, Yong Tae KimChang Duck Kim, Sun Joo Kim, Joon Soo Hahm, Yong Bum Yoon

    Research output: Contribution to journalArticlepeer-review

    63 Citations (Scopus)

    Abstract

    OBJECTIVES:: The ideal diagnostic criteria of autoimmune pancreatitis (AIP) are still challenging. Therefore, we investigated the clinical features of AIP in Korea and assessed the clinical use of new Korean diagnostic criteria. METHODS:: We reviewed 67 patients with AIP enrolled in 16 hospitals via a multicenter study. The diagnosis was confirmed according to the Korean diagnostic criteria that included pancreatic imaging, laboratory findings, histopathology, and response to steroid. RESULTS:: Mean age of the patients was 56 years, and 73% were men. Obstructive jaundice (52%) was the most common symptom, and 14 patients (21%) had other organ involvement. Fifty-four patients (81%) revealed diffuse swelling of the pancreas. Either immunoglobulin (Ig)G or IgG4 was elevated in 76%. According to the Korean criteria, 65 patients had definite diagnostic criteria, and 2 patients had probable criteria. Fifteen patients were fulfilled with image, serological, and histopathologic criteria, and 4 patients could be diagnosed with image and steroid responsiveness. Ten patients experienced recurrent attacks of AIP during the mean 20-month follow-up. CONCLUSIONS:: Among 67 cases of AIP, either IgG or IgG4 was elevated in 76% of patients, and 14 patients (21%) had other organ involvement. New Korean diagnostic criteria are useful for diagnosis of AIP.

    Original languageEnglish
    Pages (from-to)377-385
    Number of pages9
    JournalPancreas
    Volume37
    Issue number4
    DOIs
    Publication statusPublished - 2008 Nov

    Keywords

    • Autoimmune
    • Chronic pancreatitis
    • Criteria
    • Diagnosis
    • Steroid

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Hepatology
    • Endocrinology

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