Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population

Byung Joo Ham, Myoung Jin Choi, Heon Jeong Lee, Rhee Hun Kang, Min Soo Lee

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

It is well established that approximately 50% of the variance in personality traits is genetic. The goal of this study was to investigate a relationship between personality traits and the T-182C polymorphism in the norepinephrine transporter gene. The participants included 115 healthy adults with no history of psychiatric disorders and other physical illness during the past 6 months. All participants were tested with the Temperament and Character Inventory and genotyped norepinephrine transporter gene polymorphism. Differences on the Temperament and Character Inventory dimensions among three groups were examined with one-way analysis of variance. Our study suggests that the norepinephrine transporter T-182C gene polymorphism is associated with reward dependence in Koreans, but the small number of study participants and their sex and age heterogeneity limits generalization of our results. Further studies are necessary with a larger number of homogeneous participants to confirm whether the norepinephrine transporter gene is related to personality traits.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalPsychiatric Genetics
Volume15
Issue number2
DOIs
Publication statusPublished - 2005 Jun

Keywords

  • Genetics
  • Norepinephrine transporter
  • Personality traits
  • Polymorphism
  • Reward dependence

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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