Rhapontigenin converted from rhapontin purified from rheum undulatum enhances the inhibition of melanin synthesis

Hyun Sun Lee, Jeong Keun Kim, Keun Tae Park, Young Hee Lim

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1 Citation (Scopus)


Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.

Original languageEnglish
Pages (from-to)2307-2309
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number12
Publication statusPublished - 2012 Dec 1



  • Aglycone
  • Bioconversion
  • Melanin synthesis inhibition
  • Rhapontigenin
  • Tyrosinase

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

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