TY - JOUR
T1 - Rho-kinase as a target for cancer therapy and its immunotherapeutic potential
AU - Kim, Seohyun
AU - Kim, Seong A.
AU - Han, Jihoon
AU - Kim, In San
N1 - Funding Information:
Funding: This research was funded by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (2017R1A3B1023418), KU-KIST Graduate School of Converging Science and Technology Program, National Cancer Center of Korea, and KIST Institutional Programs.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment, harnessing the immune system to fight against numerous types of cancer. Rho-kinase (ROCK) pathway is involved in diverse cellular activities, and is therefore the target of interest in various diseases at the cellular level including cancer. Indeed, ROCK is well-known for its involvement in the tumor cell and tumor microenvironment, especially in its ability to enhance tumor cell progression, migration, metastasis, and extracellular matrix remodeling. Importantly, ROCK is also considered to be a novel and effective modulator of immune cells, although further studies are needed. In this review article, we describe the various activities of ROCK and its potential to be utilized in cancer treatment, particularly in cancer immunotherapy, by shining a light on its activities in the immune system.
AB - Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment, harnessing the immune system to fight against numerous types of cancer. Rho-kinase (ROCK) pathway is involved in diverse cellular activities, and is therefore the target of interest in various diseases at the cellular level including cancer. Indeed, ROCK is well-known for its involvement in the tumor cell and tumor microenvironment, especially in its ability to enhance tumor cell progression, migration, metastasis, and extracellular matrix remodeling. Importantly, ROCK is also considered to be a novel and effective modulator of immune cells, although further studies are needed. In this review article, we describe the various activities of ROCK and its potential to be utilized in cancer treatment, particularly in cancer immunotherapy, by shining a light on its activities in the immune system.
KW - Cancer immunotherapy
KW - ROCK inhibitors
KW - Rho-kinase (ROCK)
KW - Tumor microenvironment (TME)
UR - http://www.scopus.com/inward/record.url?scp=85120052989&partnerID=8YFLogxK
U2 - 10.3390/ijms222312916
DO - 10.3390/ijms222312916
M3 - Review article
C2 - 34884721
AN - SCOPUS:85120052989
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 23
M1 - 12916
ER -
