Abstract
Purpose The aim of the present randomized controlled trial was to determine the safety and efficacy of injectable demineralized bone matrix (DBM) gel combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) on alveolar ridge preservation after tooth extraction. Materials and Methods A total of 69 patients were randomly assigned to either a test group (n = 35) or a control group (n = 34). In the test group, DBM, together with rhBMP-2 (0.05 mg/mL; rhBMP-2/DBM) was transplanted into the extraction sockets. The control group received DBM alone. The safety of rhBMP-2/DBM was evaluated by oral examination, serum chemistry, and hematologic examination. The radiographic changes in alveolar bone height and width were measured using computed tomography scans performed immediately after transplant and again 3 months thereafter. Results Healing was uneventful in all subjects, with no anticipated adverse events and no clinically significant changes in the serum chemistry and hematologic findings. No meaningful immune response was found among the study groups. No significant difference was found in the radiographic changes of alveolar bone height and width (P >.05). Conclusions This new injectable biomaterial can be used easily and safely in clinical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 1281-1290 |
| Number of pages | 10 |
| Journal | Journal of Oral and Maxillofacial Surgery |
| Volume | 72 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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ASJC Scopus subject areas
- Oral Surgery
- Otorhinolaryngology
- Surgery
Cite this
Ridge preservation using demineralized bone matrix gel with recombinant human bone morphogenetic protein-2 after tooth extraction : A randomized controlled clinical trial. / Kim, Yu Jin; Lee, Jeong Yol; Kim, Jong Eun; Park, Jung Chul; Shin, Sang-Wan; Cho, Kyoo Sung.
In: Journal of Oral and Maxillofacial Surgery, Vol. 72, No. 7, 01.01.2014, p. 1281-1290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ridge preservation using demineralized bone matrix gel with recombinant human bone morphogenetic protein-2 after tooth extraction
T2 - A randomized controlled clinical trial
AU - Kim, Yu Jin
AU - Lee, Jeong Yol
AU - Kim, Jong Eun
AU - Park, Jung Chul
AU - Shin, Sang-Wan
AU - Cho, Kyoo Sung
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Purpose The aim of the present randomized controlled trial was to determine the safety and efficacy of injectable demineralized bone matrix (DBM) gel combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) on alveolar ridge preservation after tooth extraction. Materials and Methods A total of 69 patients were randomly assigned to either a test group (n = 35) or a control group (n = 34). In the test group, DBM, together with rhBMP-2 (0.05 mg/mL; rhBMP-2/DBM) was transplanted into the extraction sockets. The control group received DBM alone. The safety of rhBMP-2/DBM was evaluated by oral examination, serum chemistry, and hematologic examination. The radiographic changes in alveolar bone height and width were measured using computed tomography scans performed immediately after transplant and again 3 months thereafter. Results Healing was uneventful in all subjects, with no anticipated adverse events and no clinically significant changes in the serum chemistry and hematologic findings. No meaningful immune response was found among the study groups. No significant difference was found in the radiographic changes of alveolar bone height and width (P >.05). Conclusions This new injectable biomaterial can be used easily and safely in clinical applications.
AB - Purpose The aim of the present randomized controlled trial was to determine the safety and efficacy of injectable demineralized bone matrix (DBM) gel combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) on alveolar ridge preservation after tooth extraction. Materials and Methods A total of 69 patients were randomly assigned to either a test group (n = 35) or a control group (n = 34). In the test group, DBM, together with rhBMP-2 (0.05 mg/mL; rhBMP-2/DBM) was transplanted into the extraction sockets. The control group received DBM alone. The safety of rhBMP-2/DBM was evaluated by oral examination, serum chemistry, and hematologic examination. The radiographic changes in alveolar bone height and width were measured using computed tomography scans performed immediately after transplant and again 3 months thereafter. Results Healing was uneventful in all subjects, with no anticipated adverse events and no clinically significant changes in the serum chemistry and hematologic findings. No meaningful immune response was found among the study groups. No significant difference was found in the radiographic changes of alveolar bone height and width (P >.05). Conclusions This new injectable biomaterial can be used easily and safely in clinical applications.
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UR - http://www.scopus.com/inward/citedby.url?scp=84903178470&partnerID=8YFLogxK
U2 - 10.1016/j.joms.2014.01.022
DO - 10.1016/j.joms.2014.01.022
M3 - Article
C2 - 24709512
AN - SCOPUS:84903178470
VL - 72
SP - 1281
EP - 1290
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
SN - 0278-2391
IS - 7
ER -