Rifampin-induced pseudomembranous colitis with rectosigmoid sparing

Sun Young Yim, Ja Seol Koo, Ye Ji Kim, Sang Jung Park, Jin Nam Kim, Sung Woo Jung, Hyung Joon Yim, Sang Woo Lee, Jai Hyun Choi, Chang Duck Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pseudomembranous colitis (PMC) is known to be associated with antibiotic treatment, but is not commonly related to antitubercular (anti-TB) agent, rifampin. PMC is frequently localized to rectum and sigmoid colon, which can be diagnosed with sigmoidoscopy. We report a case of rifampin-induced PMC with rectosigmoid sparing in a pulmonary tuberculosis patient. An 81-year-old man using anti-TB agents was admitted with a 30-day history of severe diarrhea and general weakness. On colonoscopy, nonspecific findings such as mucosal edema and erosion were found in sigmoid colon, whereas multiple yellowish plaques were confined to cecal mucosa only. Biopsy specimen of the cecum was compatible with PMC. Metronidazole was started orally, and the anti-TB medications excluding rifampin were readministerred. His symptoms remarkably improved within a few days without recurrence. Awareness of rectosigmoid sparing PMC in patients who develop diarrhea during anti-TB treatment should encourage early total colonoscopy.

Original languageEnglish
Pages (from-to)137-139
Number of pages3
JournalClinical Endoscopy
Volume44
Issue number2
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Pseudomembranous Enterocolitis
Rifampin
Antitubercular Agents
Sigmoid Colon
Colonoscopy
Diarrhea
Sigmoidoscopy
Cecum
Metronidazole
Pulmonary Tuberculosis
Rectum
Edema
Mucous Membrane
Anti-Bacterial Agents
Biopsy
Recurrence
Therapeutics

Keywords

  • Antitubercular agent
  • Colonoscopy
  • Enterocolitis
  • Pseudomembranous
  • Rifampin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Rifampin-induced pseudomembranous colitis with rectosigmoid sparing. / Yim, Sun Young; Koo, Ja Seol; Kim, Ye Ji; Park, Sang Jung; Kim, Jin Nam; Jung, Sung Woo; Yim, Hyung Joon; Lee, Sang Woo; Choi, Jai Hyun; Kim, Chang Duck.

In: Clinical Endoscopy, Vol. 44, No. 2, 01.12.2011, p. 137-139.

Research output: Contribution to journalArticle

Yim, Sun Young ; Koo, Ja Seol ; Kim, Ye Ji ; Park, Sang Jung ; Kim, Jin Nam ; Jung, Sung Woo ; Yim, Hyung Joon ; Lee, Sang Woo ; Choi, Jai Hyun ; Kim, Chang Duck. / Rifampin-induced pseudomembranous colitis with rectosigmoid sparing. In: Clinical Endoscopy. 2011 ; Vol. 44, No. 2. pp. 137-139.
@article{b8fde947995c428c9ed993425d6bcbb0,
title = "Rifampin-induced pseudomembranous colitis with rectosigmoid sparing",
abstract = "Pseudomembranous colitis (PMC) is known to be associated with antibiotic treatment, but is not commonly related to antitubercular (anti-TB) agent, rifampin. PMC is frequently localized to rectum and sigmoid colon, which can be diagnosed with sigmoidoscopy. We report a case of rifampin-induced PMC with rectosigmoid sparing in a pulmonary tuberculosis patient. An 81-year-old man using anti-TB agents was admitted with a 30-day history of severe diarrhea and general weakness. On colonoscopy, nonspecific findings such as mucosal edema and erosion were found in sigmoid colon, whereas multiple yellowish plaques were confined to cecal mucosa only. Biopsy specimen of the cecum was compatible with PMC. Metronidazole was started orally, and the anti-TB medications excluding rifampin were readministerred. His symptoms remarkably improved within a few days without recurrence. Awareness of rectosigmoid sparing PMC in patients who develop diarrhea during anti-TB treatment should encourage early total colonoscopy.",
keywords = "Antitubercular agent, Colonoscopy, Enterocolitis, Pseudomembranous, Rifampin",
author = "Yim, {Sun Young} and Koo, {Ja Seol} and Kim, {Ye Ji} and Park, {Sang Jung} and Kim, {Jin Nam} and Jung, {Sung Woo} and Yim, {Hyung Joon} and Lee, {Sang Woo} and Choi, {Jai Hyun} and Kim, {Chang Duck}",
year = "2011",
month = "12",
day = "1",
doi = "10.5946/ce.2011.44.2.137",
language = "English",
volume = "44",
pages = "137--139",
journal = "Clinical Endoscopy",
issn = "2234-2400",
publisher = "Korean Society of Gastrointestinal Endoscopy",
number = "2",

}

TY - JOUR

T1 - Rifampin-induced pseudomembranous colitis with rectosigmoid sparing

AU - Yim, Sun Young

AU - Koo, Ja Seol

AU - Kim, Ye Ji

AU - Park, Sang Jung

AU - Kim, Jin Nam

AU - Jung, Sung Woo

AU - Yim, Hyung Joon

AU - Lee, Sang Woo

AU - Choi, Jai Hyun

AU - Kim, Chang Duck

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Pseudomembranous colitis (PMC) is known to be associated with antibiotic treatment, but is not commonly related to antitubercular (anti-TB) agent, rifampin. PMC is frequently localized to rectum and sigmoid colon, which can be diagnosed with sigmoidoscopy. We report a case of rifampin-induced PMC with rectosigmoid sparing in a pulmonary tuberculosis patient. An 81-year-old man using anti-TB agents was admitted with a 30-day history of severe diarrhea and general weakness. On colonoscopy, nonspecific findings such as mucosal edema and erosion were found in sigmoid colon, whereas multiple yellowish plaques were confined to cecal mucosa only. Biopsy specimen of the cecum was compatible with PMC. Metronidazole was started orally, and the anti-TB medications excluding rifampin were readministerred. His symptoms remarkably improved within a few days without recurrence. Awareness of rectosigmoid sparing PMC in patients who develop diarrhea during anti-TB treatment should encourage early total colonoscopy.

AB - Pseudomembranous colitis (PMC) is known to be associated with antibiotic treatment, but is not commonly related to antitubercular (anti-TB) agent, rifampin. PMC is frequently localized to rectum and sigmoid colon, which can be diagnosed with sigmoidoscopy. We report a case of rifampin-induced PMC with rectosigmoid sparing in a pulmonary tuberculosis patient. An 81-year-old man using anti-TB agents was admitted with a 30-day history of severe diarrhea and general weakness. On colonoscopy, nonspecific findings such as mucosal edema and erosion were found in sigmoid colon, whereas multiple yellowish plaques were confined to cecal mucosa only. Biopsy specimen of the cecum was compatible with PMC. Metronidazole was started orally, and the anti-TB medications excluding rifampin were readministerred. His symptoms remarkably improved within a few days without recurrence. Awareness of rectosigmoid sparing PMC in patients who develop diarrhea during anti-TB treatment should encourage early total colonoscopy.

KW - Antitubercular agent

KW - Colonoscopy

KW - Enterocolitis

KW - Pseudomembranous

KW - Rifampin

UR - http://www.scopus.com/inward/record.url?scp=84878719940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878719940&partnerID=8YFLogxK

U2 - 10.5946/ce.2011.44.2.137

DO - 10.5946/ce.2011.44.2.137

M3 - Article

C2 - 22741126

AN - SCOPUS:84878719940

VL - 44

SP - 137

EP - 139

JO - Clinical Endoscopy

JF - Clinical Endoscopy

SN - 2234-2400

IS - 2

ER -