Ring-opening polymerization of L-lactide and preparation of its microsphere in supercritical fluids

Ji Won Pack, Soo Hyun Kim, Sou Young Park, Youn Woo Lee, Young Ha Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The ring-opening polymerization of L-lactide initiated by stannous octoate was carried out in supercritical chlorodifluoromethane (scR22) at various reaction conditions (time and temperature) and reactant concentrations (initiator, monomer, and solvent). The monomer conversion increased to ca. 70% on increasing the reaction time to 1 h. The molecular weight of the poly(L-lactide) (PLLA) product also increased to ca. 160 000 g · mol -1 over the same period. Increasing reaction temperature from 90 to 130 °C resulted in increased monomer conversion and PLLA molecular weight. A series of polymerizations conducted at various 1-dodecanol and stannous octoate concentrations suggested that stannous octoate does not act as an initiator by itself, and that the tin-alkoxide formed from 1-dodecanol and stannous octoate serves as the initiating species in scR22. While enhancements of the monomer conversion and PLLA molecular weight were observed with increasing monomer concentration, the chlorodifluoromethane concentration had the opposite on both. After the polymerization, PLLA microspheres were prepared in situ by using a continuous supercritical antisolvent process without residual organic solvent and monomer to yield highly purified microspheres for environmental and biomedical applications.

Original languageEnglish
Pages (from-to)340-345
Number of pages6
JournalMacromolecular Bioscience
Volume4
Issue number3
DOIs
Publication statusPublished - 2004 Mar 15
Externally publishedYes

Fingerprint

Supercritical fluids
Ring opening polymerization
Microspheres
Polymerization
Dodecanol
Monomers
Molecular Weight
Molecular weight
Temperature
Tin
Organic solvents
dilactide
2-ethylhexanoic acid tin(II) salt
poly(lactide)
fluorocarbon 22

Keywords

  • Biodegradable
  • Microsphere
  • Poly(L-lactide)
  • Ring-opening polymerization
  • Supercritical fluid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry
  • Bioengineering

Cite this

Ring-opening polymerization of L-lactide and preparation of its microsphere in supercritical fluids. / Pack, Ji Won; Kim, Soo Hyun; Park, Sou Young; Lee, Youn Woo; Kim, Young Ha.

In: Macromolecular Bioscience, Vol. 4, No. 3, 15.03.2004, p. 340-345.

Research output: Contribution to journalArticle

Pack, Ji Won ; Kim, Soo Hyun ; Park, Sou Young ; Lee, Youn Woo ; Kim, Young Ha. / Ring-opening polymerization of L-lactide and preparation of its microsphere in supercritical fluids. In: Macromolecular Bioscience. 2004 ; Vol. 4, No. 3. pp. 340-345.
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