Risk assessment of hepatocellular carcinoma using transient elastography Vs. liver biopsy in chronic hepatitis b patients receiving antiviral therapy

Yeon Seok Seo, Mi Na Kim, Seung Up Kim, Sang Gyune Kim, Soon Ho Um, Kwang Hyub Han, Young Seok Kim

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    16 Citations (Scopus)

    Abstract

    Liver stiffness (LS) assessed using transient elastography (TE) can assess the risk of developing hepatocellular carcinoma (HCC). We evaluated whether TE, when compared with histological data as a reference standard, can predict the risk of HCC development in chronic hepatitis B (CHB) patients starting antiviral therapy. Observational cohort database of 381 patients with CHB who underwent liver biopsy (LB) and TE were reviewed. All patients underwent surveillance for HCC development using ultrasonography and alpha-fetoprotein. During the median follow-up period of 48.1 (interquartile range 30.3-69.3) months, HCC developed in 34 (8.9%) patients. In patients with HCC development, age, proportion of diabetes mellitus, histological fibrosis stage, and LS value were significantly higher than those in patients without (all P<0.05). The cumulative incidence rates of HCC increased significantly in association with elevated LS value in 3 stratified groups (LS value <8, 8-13, and >13 kPa; log-rank test, P<0.001), and with higher histological fibrosis stage in 3 stratified groups (F0-2, F3, and F4; log-rank test, P<0.001). On multivariate analysis, along with age, LS value was an independent predictor of HCC development (hazard ratio 1.041, P<0.001), whereas histological staging was not (P>0.05). TE predicted HCC development independently in patients with CHB starting antiviral therapy. However, further investigation is needed to determine whether the current surveillance strategy can be optimized based on the LS value at the time of starting antiviral therapy.

    Original languageEnglish
    Article numbere2985
    JournalMedicine (United States)
    Volume95
    Issue number12
    DOIs
    Publication statusPublished - 2016

    ASJC Scopus subject areas

    • Medicine(all)

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