Risk factors for isolation of low-level mupirocin-resistant versus -susceptible methicillin-resistant Staphylococcus aureus from patients in intensive care units

Dae Won Park, Ja Kim Min, Jin Ah Yang, Hye Won Jeong, Jang Wook Sohn, Byung-Chul Chun

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: The aim of this study was to determine the risk factors for the recovery of low-level mupirocin-resistant (mupr) or -susceptible (mups) MRSA from patients in intensive care units (ICUs). Methods: A case-case-control study was conducted from November 2003 to April 2004. Two case groups consisted of patients with low-level mupr MRSA and mups MRSA. A control group was frequency matched. Results: Mupr MRSA and mups MRSA were isolated from 20 to 51 patients, respectively, during a six-month period. Risk factors identified for mupr MRSA were as follows: exposure to piperacillin-tazobactam (odds ratio [OR] 13.8; 95% confidence intervals [CI], 1.8-105.0), third-generation cephalosporins (OR, 5.0; 95% CI, 1.6-15.5) and quinolones (OR, 3.4; 95% CI, 1.1-10.7). Risk factors identified for mups MRSA were as follows: length of ICU stay (OR, 1.1; 95% CI, 1.0-1.1), surgery (OR, 3.7; 95% CI, 1.5-9.0), exposure to third-generation cephalosporins (OR, 8.4; 95% CI, 3.3-21.7) and quinolones (OR, 7.7; 95% CI, 2.8-21.3). Conclusions: Our results suggest that nosocomial isolation of low-level mupr MRSA may be affected by piperacillin-tazobactam.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalJournal of Infection
Volume54
Issue number4
DOIs
Publication statusPublished - 2007 Apr 1
Externally publishedYes

Fingerprint

Mupirocin
Methicillin-Resistant Staphylococcus aureus
Intensive Care Units
Odds Ratio
Confidence Intervals
Quinolones
Cephalosporins
Case-Control Studies
Control Groups

Keywords

  • MRSA
  • Mupirocin
  • Piperacillin-tazobactam
  • Resistance
  • Risk factors

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

@article{1ea5556cbcaa45be9c8770d043f087de,
title = "Risk factors for isolation of low-level mupirocin-resistant versus -susceptible methicillin-resistant Staphylococcus aureus from patients in intensive care units",
abstract = "Objectives: The aim of this study was to determine the risk factors for the recovery of low-level mupirocin-resistant (mupr) or -susceptible (mups) MRSA from patients in intensive care units (ICUs). Methods: A case-case-control study was conducted from November 2003 to April 2004. Two case groups consisted of patients with low-level mupr MRSA and mups MRSA. A control group was frequency matched. Results: Mupr MRSA and mups MRSA were isolated from 20 to 51 patients, respectively, during a six-month period. Risk factors identified for mupr MRSA were as follows: exposure to piperacillin-tazobactam (odds ratio [OR] 13.8; 95{\%} confidence intervals [CI], 1.8-105.0), third-generation cephalosporins (OR, 5.0; 95{\%} CI, 1.6-15.5) and quinolones (OR, 3.4; 95{\%} CI, 1.1-10.7). Risk factors identified for mups MRSA were as follows: length of ICU stay (OR, 1.1; 95{\%} CI, 1.0-1.1), surgery (OR, 3.7; 95{\%} CI, 1.5-9.0), exposure to third-generation cephalosporins (OR, 8.4; 95{\%} CI, 3.3-21.7) and quinolones (OR, 7.7; 95{\%} CI, 2.8-21.3). Conclusions: Our results suggest that nosocomial isolation of low-level mupr MRSA may be affected by piperacillin-tazobactam.",
keywords = "MRSA, Mupirocin, Piperacillin-tazobactam, Resistance, Risk factors",
author = "Park, {Dae Won} and Min, {Ja Kim} and Yang, {Jin Ah} and Jeong, {Hye Won} and Sohn, {Jang Wook} and Byung-Chul Chun",
year = "2007",
month = "4",
day = "1",
doi = "10.1016/j.jinf.2006.06.008",
language = "English",
volume = "54",
pages = "337--342",
journal = "Journal of Infection",
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T1 - Risk factors for isolation of low-level mupirocin-resistant versus -susceptible methicillin-resistant Staphylococcus aureus from patients in intensive care units

AU - Park, Dae Won

AU - Min, Ja Kim

AU - Yang, Jin Ah

AU - Jeong, Hye Won

AU - Sohn, Jang Wook

AU - Chun, Byung-Chul

PY - 2007/4/1

Y1 - 2007/4/1

N2 - Objectives: The aim of this study was to determine the risk factors for the recovery of low-level mupirocin-resistant (mupr) or -susceptible (mups) MRSA from patients in intensive care units (ICUs). Methods: A case-case-control study was conducted from November 2003 to April 2004. Two case groups consisted of patients with low-level mupr MRSA and mups MRSA. A control group was frequency matched. Results: Mupr MRSA and mups MRSA were isolated from 20 to 51 patients, respectively, during a six-month period. Risk factors identified for mupr MRSA were as follows: exposure to piperacillin-tazobactam (odds ratio [OR] 13.8; 95% confidence intervals [CI], 1.8-105.0), third-generation cephalosporins (OR, 5.0; 95% CI, 1.6-15.5) and quinolones (OR, 3.4; 95% CI, 1.1-10.7). Risk factors identified for mups MRSA were as follows: length of ICU stay (OR, 1.1; 95% CI, 1.0-1.1), surgery (OR, 3.7; 95% CI, 1.5-9.0), exposure to third-generation cephalosporins (OR, 8.4; 95% CI, 3.3-21.7) and quinolones (OR, 7.7; 95% CI, 2.8-21.3). Conclusions: Our results suggest that nosocomial isolation of low-level mupr MRSA may be affected by piperacillin-tazobactam.

AB - Objectives: The aim of this study was to determine the risk factors for the recovery of low-level mupirocin-resistant (mupr) or -susceptible (mups) MRSA from patients in intensive care units (ICUs). Methods: A case-case-control study was conducted from November 2003 to April 2004. Two case groups consisted of patients with low-level mupr MRSA and mups MRSA. A control group was frequency matched. Results: Mupr MRSA and mups MRSA were isolated from 20 to 51 patients, respectively, during a six-month period. Risk factors identified for mupr MRSA were as follows: exposure to piperacillin-tazobactam (odds ratio [OR] 13.8; 95% confidence intervals [CI], 1.8-105.0), third-generation cephalosporins (OR, 5.0; 95% CI, 1.6-15.5) and quinolones (OR, 3.4; 95% CI, 1.1-10.7). Risk factors identified for mups MRSA were as follows: length of ICU stay (OR, 1.1; 95% CI, 1.0-1.1), surgery (OR, 3.7; 95% CI, 1.5-9.0), exposure to third-generation cephalosporins (OR, 8.4; 95% CI, 3.3-21.7) and quinolones (OR, 7.7; 95% CI, 2.8-21.3). Conclusions: Our results suggest that nosocomial isolation of low-level mupr MRSA may be affected by piperacillin-tazobactam.

KW - MRSA

KW - Mupirocin

KW - Piperacillin-tazobactam

KW - Resistance

KW - Risk factors

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DO - 10.1016/j.jinf.2006.06.008

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C2 - 16860870

AN - SCOPUS:33947148215

VL - 54

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JO - Journal of Infection

JF - Journal of Infection

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