Risk factors for isolation of low-level mupirocin-resistant versus -susceptible methicillin-resistant Staphylococcus aureus from patients in intensive care units

Dae Won Park, Min Ja Kim, Jin Ah Yang, Hye Won Jeong, Jang Wook Sohn, Byung Chul Chun

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: The aim of this study was to determine the risk factors for the recovery of low-level mupirocin-resistant (mupr) or -susceptible (mups) MRSA from patients in intensive care units (ICUs). Methods: A case-case-control study was conducted from November 2003 to April 2004. Two case groups consisted of patients with low-level mupr MRSA and mups MRSA. A control group was frequency matched. Results: Mupr MRSA and mups MRSA were isolated from 20 to 51 patients, respectively, during a six-month period. Risk factors identified for mupr MRSA were as follows: exposure to piperacillin-tazobactam (odds ratio [OR] 13.8; 95% confidence intervals [CI], 1.8-105.0), third-generation cephalosporins (OR, 5.0; 95% CI, 1.6-15.5) and quinolones (OR, 3.4; 95% CI, 1.1-10.7). Risk factors identified for mups MRSA were as follows: length of ICU stay (OR, 1.1; 95% CI, 1.0-1.1), surgery (OR, 3.7; 95% CI, 1.5-9.0), exposure to third-generation cephalosporins (OR, 8.4; 95% CI, 3.3-21.7) and quinolones (OR, 7.7; 95% CI, 2.8-21.3). Conclusions: Our results suggest that nosocomial isolation of low-level mupr MRSA may be affected by piperacillin-tazobactam.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalJournal of Infection
Volume54
Issue number4
DOIs
Publication statusPublished - 2007 Apr 1

Keywords

  • MRSA
  • Mupirocin
  • Piperacillin-tazobactam
  • Resistance
  • Risk factors

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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