Risk of Adverse Obstetric Outcomes and the Abnormal Growth of Offspring in Women with a History of Thyroid Cancer

Geum-Joon Cho, So Youn Kim, Hoi Chang Lee, Kyu Min Lee, Sung Won Han, Min Jeong Oh, Teresa K. Woodruff

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: It is unclear whether a history of thyroid cancer is associated with an increased risk of adverse pregnancy outcomes in subsequent pregnancies. This study aimed to evaluate the risk of adverse obstetric outcomes and the abnormal growth of offspring in women with a history of thyroid cancer. Methods: This retrospective observational study used nationwide data from between 2006 and 2014 to compare pregnancy outcomes of women with a history of thyroid cancer and those with no such history. Cases of thyroid cancer were identified using ICD-10 codes. Results: During the study period, 7232 women with a history of thyroid cancer and 2,269,051 women without a history of thyroid cancer gave birth. The risks of cesarean section, preterm birth, low birth weight, large for gestational age, preeclampsia, placental abruption, placenta previa, and stillbirth were not different between the groups. Women with a history of thyroid cancer had a statistically higher risk of postpartum hemorrhage (odds ratio [OR] = 1.23 [confidence interval (CI) 1.15-1.32], p < 0.05, corrected with the false discovery rate). Additionally, generalized estimating equations analysis showed that there was no difference in the risk of underweight (OR = 1.05 [CI 0.93-1.19]) and obese (OR = 0.94 [CI 0.84-1.05]) offspring assessed over a period of 80 months after adjusting for confounding factors. Conclusions: Women with a history of thyroid cancer have similar pregnancy outcomes and offspring growth to those with no such history.

Original languageEnglish
Pages (from-to)879-885
Number of pages7
JournalThyroid
Volume29
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

Fingerprint

Thyroid Neoplasms
Obstetrics
Growth
Pregnancy Outcome
Odds Ratio
International Classification of Diseases
Confidence Intervals
History
Placenta Previa
Abruptio Placentae
Postpartum Hemorrhage
Stillbirth
Thinness
Premature Birth
Low Birth Weight Infant
Pre-Eclampsia
Cesarean Section
Gestational Age
Observational Studies
Retrospective Studies

Keywords

  • adverse outcome
  • pregnancy
  • thyroid cancer

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Risk of Adverse Obstetric Outcomes and the Abnormal Growth of Offspring in Women with a History of Thyroid Cancer. / Cho, Geum-Joon; Kim, So Youn; Lee, Hoi Chang; Lee, Kyu Min; Han, Sung Won; Oh, Min Jeong; Woodruff, Teresa K.

In: Thyroid, Vol. 29, No. 6, 01.06.2019, p. 879-885.

Research output: Contribution to journalArticle

Cho, Geum-Joon ; Kim, So Youn ; Lee, Hoi Chang ; Lee, Kyu Min ; Han, Sung Won ; Oh, Min Jeong ; Woodruff, Teresa K. / Risk of Adverse Obstetric Outcomes and the Abnormal Growth of Offspring in Women with a History of Thyroid Cancer. In: Thyroid. 2019 ; Vol. 29, No. 6. pp. 879-885.
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