Risk of early childhood obesity in offspring of women with preeclampsia: A population-based study

Seung Woo Yang, Min Jeong Oh, Keon Vin Park, Sung Won Han, Hee Sun Kim, In Sook Sohn, Han Sung Kwon, Geum Joon Cho, Han Sung Hwang

Research output: Contribution to journalArticlepeer-review

Abstract

Preeclampsia (PE) is a major disease of pregnancy, with various short-or long-term complications for both the mother and offspring. We focused on the body mass index (BMI) of offspring and compared the incidence of obesity during early childhood between PE-and nonPE-affected pregnancies. Women with singleton births (n = 1,697,432) were identified from the Korea National Health Insurance database. The outcomes of offspring at 30–80 months of age were analyzed. The effects of PE on BMI and the incidence of obesity in the offspring were compared. The incidence of low birth weight (LBW) offspring was higher in the PE group (n = 29,710) than that in the non-PE group (n = 1,533,916) (24.70% vs. 3.33%, p < 0.01). However, BMI was significantly higher in the PE-affected offspring than that in non-PE-affected offspring. After adjusting for various factors, the risk of obesity was higher in the PE-affected offspring (odds ratio = 1.34, 95% confidence interval = 1.30–1.38). The BMI and incidence of obesity were higher during early childhood in the PE-affected offspring, even though the proportion of LBW was higher. These results may support the basic hypotheses for the occurrence of various cardiovascular and metabolic complications in PE-affected offspring. In addition, early-age incidence of obesity could influence PE management and child consultation in clinical applications.

Original languageEnglish
Article number3758
JournalJournal of Clinical Medicine
Volume10
Issue number16
DOIs
Publication statusPublished - 2021 Aug 2

Keywords

  • Body mass index
  • Early childhood offspring
  • Obesity
  • Preeclampsia

ASJC Scopus subject areas

  • Medicine(all)

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