Robotic system-based fractionated stereotactic radiotherapy in locally recurrent nasopharyngeal carcinoma

Young Seok Seo, Hyung Jun Yoo, Sung Yul Yoo, Chul Koo Cho, Kwang Mo Yang, Mi Sook Kim, Chul Won Choi, Young Ju Shin, Dong Han Lee, Guk Hang Lee

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28 Citations (Scopus)

Abstract

Purpose: We reviewed survival, local control, and toxicity in patients with locally recurrent nasopharyngeal carcinoma (NPC) who had been treated with fractionated stereotactic radiotherapy (FSRT). Materials and methods: Between June 2002 and March 2008, we retrospectively reviewed 35 patients with locally recurrent NPC treated using FSRT with CyberKnife. Gross tumor volumes ranged from 2.6 to 64.0 ml (median, 7.9 ml). Radiation doses were prescribed at the isodose line (75-84% of the maximum dose; median, 80%). The prescribed dose of FSRT ranged from 24 to 45 Gy (median, 33 Gy) in three or five fractions. Results: The overall survival (OS) rate, local failure-free survival (LFFS) rate, and disease progression-free survival (DPFS) rate at 5 years were 60%, 79%, and 74%, respectively. Twenty-three patients achieved complete response after FSRT. Only T stage at recurrence was an independent prognostic factor for OS and DPFS. Five patients exhibited severe late toxicity (Grade 4 or 5). Conclusions: With regard to OS and LFFS, our study provided favorable outcomes. The incidence of severe late toxicities was acceptable in our study. FSRT would be considered as the alternative treatment of choice in re-irradiation for locally recurrent NPC.

Original languageEnglish
Pages (from-to)570-574
Number of pages5
JournalRadiotherapy and Oncology
Volume93
Issue number3
DOIs
Publication statusPublished - 2009 Dec

Keywords

  • CyberKnife
  • Fractionation
  • Recurrent nasopharyngeal carcinoma
  • Stereotactic

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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    Seo, Y. S., Yoo, H. J., Yoo, S. Y., Cho, C. K., Yang, K. M., Kim, M. S., Choi, C. W., Shin, Y. J., Lee, D. H., & Lee, G. H. (2009). Robotic system-based fractionated stereotactic radiotherapy in locally recurrent nasopharyngeal carcinoma. Radiotherapy and Oncology, 93(3), 570-574. https://doi.org/10.1016/j.radonc.2009.10.018