Robust deformable-surface-based skull-stripping for large-scale studies

Yaping Wang, Jingxin Nie, Pew Thian Yap, Feng Shi, Lei Guo, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Skull-stripping refers to the separation of brain tissue from non-brain tissue, such as the scalp, skull, and dura. In large-scale studies involving a significant number of subjects, a fully automatic method is highly desirable, since manual skull-stripping requires tremendous human effort and can be inconsistent even after sufficient training. We propose in this paper a robust and effective method that is capable of skull-stripping a large number of images accurately with minimal dependence on the parameter setting. The key of our method involves an initial skull-stripping by co-registration of an atlas, followed by a refinement phase with a surface deformation scheme that is guided by prior information obtained from a set of real brain images. Evaluation based on a total of 831 images, consisting of normal controls (NC) and patients with mild cognitive impairment (MCI) or Alzheimer's Disease (AD), from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database indicates that our method performs favorably at a consistent overall overlap rate of approximately 98% when compared with expert results. The software package will be made available to the public to facilitate neuroimaging studies.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages635-642
Number of pages8
Volume6893 LNCS
EditionPART 3
DOIs
Publication statusPublished - 2011 Oct 11
Externally publishedYes
Event14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011 - Toronto, ON, Canada
Duration: 2011 Sep 182011 Sep 22

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 3
Volume6893 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011
CountryCanada
CityToronto, ON
Period11/9/1811/9/22

Fingerprint

Neuroimaging
Brain
Tissue
Alzheimer's Disease
Software packages
Atlas
Prior Information
Software Package
Inconsistent
Registration
Overlap
Refinement
Sufficient
Evaluation

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Wang, Y., Nie, J., Yap, P. T., Shi, F., Guo, L., & Shen, D. (2011). Robust deformable-surface-based skull-stripping for large-scale studies. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (PART 3 ed., Vol. 6893 LNCS, pp. 635-642). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6893 LNCS, No. PART 3). https://doi.org/10.1007/978-3-642-23626-6_78

Robust deformable-surface-based skull-stripping for large-scale studies. / Wang, Yaping; Nie, Jingxin; Yap, Pew Thian; Shi, Feng; Guo, Lei; Shen, Dinggang.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 6893 LNCS PART 3. ed. 2011. p. 635-642 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6893 LNCS, No. PART 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, Y, Nie, J, Yap, PT, Shi, F, Guo, L & Shen, D 2011, Robust deformable-surface-based skull-stripping for large-scale studies. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). PART 3 edn, vol. 6893 LNCS, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), no. PART 3, vol. 6893 LNCS, pp. 635-642, 14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011, Toronto, ON, Canada, 11/9/18. https://doi.org/10.1007/978-3-642-23626-6_78
Wang Y, Nie J, Yap PT, Shi F, Guo L, Shen D. Robust deformable-surface-based skull-stripping for large-scale studies. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). PART 3 ed. Vol. 6893 LNCS. 2011. p. 635-642. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 3). https://doi.org/10.1007/978-3-642-23626-6_78
Wang, Yaping ; Nie, Jingxin ; Yap, Pew Thian ; Shi, Feng ; Guo, Lei ; Shen, Dinggang. / Robust deformable-surface-based skull-stripping for large-scale studies. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 6893 LNCS PART 3. ed. 2011. pp. 635-642 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 3).
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