Robust Fusion of Diffusion MRI Data for Template Construction

Zhanlong Yang, Geng Chen, Dinggang Shen, Pew Thian Yap

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Construction of brain templates is generally carried out using a two-step procedure involving registering a population of images to a common space and then fusing the aligned images to form a template. In practice, image registration is not perfect and simple averaging of the images will blur structures and cause artifacts. In diffusion MRI, this is further complicated by intra-voxel inter-subject differences in fiber orientation, fiber configuration, anisotropy, and diffusivity. In this paper, we propose a method to improve the construction of diffusion MRI templates in light of inter-subject differences. Our method involves a novel q-space (i.e., wavevector space) patch matching mechanism that is incorporated in a mean shift algorithm to seek the most probable signal at each point in q-space. Our method relies on the fact that the mean shift algorithm is a mode seeking algorithm that converges to the mode of a distribution and is hence robust to outliers. Our method is therefore in effect seeking the most probable signal profile at each voxel given a distribution of signal profiles. Experimental results show that our method yields diffusion MRI templates with cleaner fiber orientations and less artifacts caused by inter-subject differences in fiber orientation.

Original languageEnglish
Article number12950
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

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Magnetic resonance imaging
Fusion reactions
Fiber reinforced materials
Image registration
Brain
Anisotropy
Fibers

ASJC Scopus subject areas

  • General

Cite this

Robust Fusion of Diffusion MRI Data for Template Construction. / Yang, Zhanlong; Chen, Geng; Shen, Dinggang; Yap, Pew Thian.

In: Scientific Reports, Vol. 7, No. 1, 12950, 01.12.2017.

Research output: Contribution to journalArticle

Yang, Zhanlong ; Chen, Geng ; Shen, Dinggang ; Yap, Pew Thian. / Robust Fusion of Diffusion MRI Data for Template Construction. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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