Robust ZnO nanoparticle embedded memory device using vancomycin conjugate and its biorecognition for electrical charging node

Minkeun Kim, Hye Jin Lee, Sewook Oh, Yejin Kim, Hunsang Jung, Min Kyu Oh, Yeo Joon Yoon, Tae Hyeon Yoo, Tae Sik Yoon, Hyun Ho Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Conjugation of antibiotic vancomycin (VAN) on nanoparticles (NPs) has recently initiated novel works in the nanobiotechnology field. In this study, a bioelectronic structure using VAN conjugated zinc oxide (ZnO) NPs as charge storing elements on metal-pentacene-insulator-silicon (MPIS) device is demonstrated. Highly specific molecular recognition between the VAN and membrane protein unit mimicked from VAN-resistant bacteria is employed as the formation mechanism of self-assembly monolayers (SAMs) of ZnO NPs. The insulator surface is modified with the VAN cognate peptide of l-Ala-d-Glu-l-Lys-d-Ala-d-Ala by chemical activator coupling. Hysteretic behaviors in capacitance versus voltage (C-V) curves are obtained for the charged ZnO NPs exhibiting flatband voltage shifts, which demonstrate the charge storage on the VAN conjugated ZnO NPs. The potential perspective of this study will be a tangible progress of biomolecular electronics implemented by the interface between biomolecules and electronics.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalBiosensors and Bioelectronics
Volume56
DOIs
Publication statusPublished - 2014 Jun 15

Keywords

  • Bioelectronics
  • Biorecognition
  • Memory device
  • Self-assembly monolayer
  • Vancomycin
  • ZnO nanoparticles

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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