Role of Arabidopsis Pumilio RNA binding protein 5 in virus infection

Sung Un Huh, Kyung Hee Paek

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Regulation of gene expression is mediated by diverse RNA binding proteins which play important roles in development and defense processes. Pumilio/FBF (Puf) protein in mammals functions as a posttranscriptional/translational repressor by binding to the 3' UTR regions of its target mRNAs. Previous study reported that APUM5 provides protection against CMV infection by directly binding to CMV RNAs in Arabidopsis. CMV RNAs contain putative Pumilio-binding motifs and APUM5 bound to the 3' UTR and some of its internal motifs both in vitro and in vivo. APUM5 works as a negative regulator of the 3' UTR of CMV and it might regulate CMV replication. Our findings suggest that APUM5 acts as a defensive repressor in plants during CMV infection. However, functions of APUM5 and other APUM members are still not clear and more studies are needed to find out the interacting partners and target mRNAs in host plant.

Original languageEnglish
JournalPlant Signaling and Behavior
Volume8
Issue number5
DOIs
Publication statusPublished - 2013 May 1

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RNA-binding proteins
3' untranslated regions
Arabidopsis
viruses
infection
RNA
gene expression regulation
host plants
mammals
proteins

Keywords

  • Cucumber mosaic virus (CMV)
  • hunchback (hb)
  • Pumilio homology domain (PHD)
  • Pumilio/FBF (Puf) protein
  • RNA-binding proteins (RBPs)

ASJC Scopus subject areas

  • Plant Science

Cite this

Role of Arabidopsis Pumilio RNA binding protein 5 in virus infection. / Un Huh, Sung; Paek, Kyung Hee.

In: Plant Signaling and Behavior, Vol. 8, No. 5, 01.05.2013.

Research output: Contribution to journalArticle

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