Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis

Jae Keun Lee, Jin Hee Shin, Ji Eun Lee, Eui Ju Choi

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease characterized by the selective degeneration of upper and lower motor neurons associated with the abnormal aggregation of ubiquitinated proteins. The molecular mechanisms underlying the pathogenesis of ALS remain unclear, however. Autophagy is a major pathway for the elimination of protein aggregates and damaged organelles and therefore contributes to cellular homeostasis. This catabolic process begins with the formation of the double membrane-bound autophagosome that engulfs portions of the cytoplasm and subsequently fuses with a lysosome to form an autolysosome, in which lysosomal enzymes digest autophagic substrates. Defects at various stages of autophagy have been associated with pathological mutations of several ALS-linked genes including SOD1, p62, TDP-43, and optineurin, suggesting that such defects may play a causative role in the pathogenesis of this condition. In this review, we summarize the dysregulation of autophagy associated with ALS as well as potential therapeutic strategies based on modulation of the autophagic process.

Original languageEnglish
Article number64284
Pages (from-to)2517-2524
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1852
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

Keywords

  • Amyotrophic lateral sclerosis
  • Autophagosome
  • Autophagy
  • Lysosome
  • Neurodegeneration

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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