Role of body mass index as a risk and prognostic factor of endometrioid uterine cancer in Korean women

Nan Hee Jeong, Jong Min Lee, Jae Kwan Lee, Jae Weon Kim, Chi Heum Cho, Seok Mo Kim, Sang Soo Seo, Chan Yong Park, Ki Tae Kim, Juneyoung Lee

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: We aimed to evaluate the role of body mass index (BMI) as a risk and prognostic factor of endometrioid uterine cancer in Korean women. Methods: The records of 937 patients with endometrioid uterine cancer treated between 2000 and 2006 in Korea were reviewed. To determine the disease risk by BMI, four age-matched controls were recruited from healthy women (1-year age group). Results: The obese (BMI ≥ 25 kg/m2) and overweight (23 kg/m2≤ BMI < 25 kg/m2) women had an increased risk for endometrioid uterine cancer (OR = 3.161, 95% CI = 2.655-3.763 and OR = 1.536, 95% CI = 1.260-1.873, respectively) compared to the non-obese (BMI < 23 kg/m2) women. That is, an increment of 1 kg/m2 caused an 18% increase in the endometrioid uterine cancer risk (OR = 1.181, 95% CI = 1.155-1.207). However, there was no difference in overall survival according to the BMI-based subgroups (log-rank = 0.366, p = 0.8328). The crude Cox model showed that obesity was not associated with the patients' overall survival when the obese and non-obese women were compared (crude HR = 0.82, 95% CI = 0.40-1.66). Furthermore, there was a significant trend toward a better prognosis at increased increments of BMI (p for trend < 0.001), but this was not found in the multivariate analysis. Conclusions: A high BMI was a significant risk factor for endometrioid uterine cancer in an Asian population. However, it was not associated with overall survival, in spite of the earlier tumor stage of the obese women.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalGynecologic Oncology
Volume118
Issue number1
DOIs
Publication statusPublished - 2010 Jul 1

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Uterine Neoplasms
Body Mass Index
Survival
Korea
Proportional Hazards Models
Multivariate Analysis
Age Groups
Obesity

Keywords

  • Body mass index
  • Endometrioid
  • Prognosis
  • Risk
  • Uterine cancer

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Role of body mass index as a risk and prognostic factor of endometrioid uterine cancer in Korean women. / Jeong, Nan Hee; Lee, Jong Min; Lee, Jae Kwan; Kim, Jae Weon; Cho, Chi Heum; Kim, Seok Mo; Seo, Sang Soo; Park, Chan Yong; Kim, Ki Tae; Lee, Juneyoung.

In: Gynecologic Oncology, Vol. 118, No. 1, 01.07.2010, p. 24-28.

Research output: Contribution to journalArticle

Jeong, Nan Hee ; Lee, Jong Min ; Lee, Jae Kwan ; Kim, Jae Weon ; Cho, Chi Heum ; Kim, Seok Mo ; Seo, Sang Soo ; Park, Chan Yong ; Kim, Ki Tae ; Lee, Juneyoung. / Role of body mass index as a risk and prognostic factor of endometrioid uterine cancer in Korean women. In: Gynecologic Oncology. 2010 ; Vol. 118, No. 1. pp. 24-28.
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abstract = "Objective: We aimed to evaluate the role of body mass index (BMI) as a risk and prognostic factor of endometrioid uterine cancer in Korean women. Methods: The records of 937 patients with endometrioid uterine cancer treated between 2000 and 2006 in Korea were reviewed. To determine the disease risk by BMI, four age-matched controls were recruited from healthy women (1-year age group). Results: The obese (BMI ≥ 25 kg/m2) and overweight (23 kg/m2≤ BMI < 25 kg/m2) women had an increased risk for endometrioid uterine cancer (OR = 3.161, 95{\%} CI = 2.655-3.763 and OR = 1.536, 95{\%} CI = 1.260-1.873, respectively) compared to the non-obese (BMI < 23 kg/m2) women. That is, an increment of 1 kg/m2 caused an 18{\%} increase in the endometrioid uterine cancer risk (OR = 1.181, 95{\%} CI = 1.155-1.207). However, there was no difference in overall survival according to the BMI-based subgroups (log-rank = 0.366, p = 0.8328). The crude Cox model showed that obesity was not associated with the patients' overall survival when the obese and non-obese women were compared (crude HR = 0.82, 95{\%} CI = 0.40-1.66). Furthermore, there was a significant trend toward a better prognosis at increased increments of BMI (p for trend < 0.001), but this was not found in the multivariate analysis. Conclusions: A high BMI was a significant risk factor for endometrioid uterine cancer in an Asian population. However, it was not associated with overall survival, in spite of the earlier tumor stage of the obese women.",
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AU - Jeong, Nan Hee

AU - Lee, Jong Min

AU - Lee, Jae Kwan

AU - Kim, Jae Weon

AU - Cho, Chi Heum

AU - Kim, Seok Mo

AU - Seo, Sang Soo

AU - Park, Chan Yong

AU - Kim, Ki Tae

AU - Lee, Juneyoung

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N2 - Objective: We aimed to evaluate the role of body mass index (BMI) as a risk and prognostic factor of endometrioid uterine cancer in Korean women. Methods: The records of 937 patients with endometrioid uterine cancer treated between 2000 and 2006 in Korea were reviewed. To determine the disease risk by BMI, four age-matched controls were recruited from healthy women (1-year age group). Results: The obese (BMI ≥ 25 kg/m2) and overweight (23 kg/m2≤ BMI < 25 kg/m2) women had an increased risk for endometrioid uterine cancer (OR = 3.161, 95% CI = 2.655-3.763 and OR = 1.536, 95% CI = 1.260-1.873, respectively) compared to the non-obese (BMI < 23 kg/m2) women. That is, an increment of 1 kg/m2 caused an 18% increase in the endometrioid uterine cancer risk (OR = 1.181, 95% CI = 1.155-1.207). However, there was no difference in overall survival according to the BMI-based subgroups (log-rank = 0.366, p = 0.8328). The crude Cox model showed that obesity was not associated with the patients' overall survival when the obese and non-obese women were compared (crude HR = 0.82, 95% CI = 0.40-1.66). Furthermore, there was a significant trend toward a better prognosis at increased increments of BMI (p for trend < 0.001), but this was not found in the multivariate analysis. Conclusions: A high BMI was a significant risk factor for endometrioid uterine cancer in an Asian population. However, it was not associated with overall survival, in spite of the earlier tumor stage of the obese women.

AB - Objective: We aimed to evaluate the role of body mass index (BMI) as a risk and prognostic factor of endometrioid uterine cancer in Korean women. Methods: The records of 937 patients with endometrioid uterine cancer treated between 2000 and 2006 in Korea were reviewed. To determine the disease risk by BMI, four age-matched controls were recruited from healthy women (1-year age group). Results: The obese (BMI ≥ 25 kg/m2) and overweight (23 kg/m2≤ BMI < 25 kg/m2) women had an increased risk for endometrioid uterine cancer (OR = 3.161, 95% CI = 2.655-3.763 and OR = 1.536, 95% CI = 1.260-1.873, respectively) compared to the non-obese (BMI < 23 kg/m2) women. That is, an increment of 1 kg/m2 caused an 18% increase in the endometrioid uterine cancer risk (OR = 1.181, 95% CI = 1.155-1.207). However, there was no difference in overall survival according to the BMI-based subgroups (log-rank = 0.366, p = 0.8328). The crude Cox model showed that obesity was not associated with the patients' overall survival when the obese and non-obese women were compared (crude HR = 0.82, 95% CI = 0.40-1.66). Furthermore, there was a significant trend toward a better prognosis at increased increments of BMI (p for trend < 0.001), but this was not found in the multivariate analysis. Conclusions: A high BMI was a significant risk factor for endometrioid uterine cancer in an Asian population. However, it was not associated with overall survival, in spite of the earlier tumor stage of the obese women.

KW - Body mass index

KW - Endometrioid

KW - Prognosis

KW - Risk

KW - Uterine cancer

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